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Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation
Joint Authors
Jia, Renyong
Yang, Yi
Luo, Huihui
Song, Xu
Yu, Li
Xie, Juan
Yang, Jiajie
Lin, Juchun
Zou, Yuanfeng
Li, Lixia
Yin, Lizi
He, Changliang
Liang, Xiaoxia
Yue, Guizhou
Yin, Zhongqiong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background of the Study.
As a widely used traditional medicine, Galla Chinensis is rich in tannins.
However, there are few detailed studies about pharmaceutical preparations of Galla Chinensis tannin extract (GTE).
In the present experiments, for better application and to investigate the possibility that Galla Chinensis tannin extract can be used as an antidiarrheal drug, we prepared Galla Chinensis oral solution (GOS).
Materials and Methods.
GOS was prepared with GTE, and its physicochemical and microbiological stability was evaluated.
The oral acute toxicity of GOS was calculated by the 50% lethal dose (LD50).
The antidiarrheal activity was determined in a castor oil-induced diarrhea model in mice through diarrhea symptoms, fluid accumulation ratio, and percentage of distance moved by charcoal meal.
Results.
The tannin content of GTE was 47.75%.
GOS could endure a high temperature without a significant decrease of tannin content.
After storage for six months, the tannin content of GOS was still more than 90%.
GOS was determined to be nontoxic.
Meanwhile, GOS showed significant antidiarrheal activity in a castor oil-induced diarrhea model in mice (P<0.01).
Conclusion.
The results suggested that GOS is an effective and stable antidiarrheal drug that can be used to complement other therapies.
American Psychological Association (APA)
Yang, Yi& Luo, Huihui& Song, Xu& Yu, Li& Xie, Juan& Yang, Jiajie…[et al.]. 2017. Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153124
Modern Language Association (MLA)
Yang, Yi…[et al.]. Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153124
American Medical Association (AMA)
Yang, Yi& Luo, Huihui& Song, Xu& Yu, Li& Xie, Juan& Yang, Jiajie…[et al.]. Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153124