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The Potential of Angiogenin as a Serum Biomarker for Diseases: Systematic Review and Meta-Analysis
Joint Authors
Yu, Dongdong
Cai, Yikai
Zhou, Wei
Sheng, Jinghao
Xu, Zhengping
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Angiogenin (ANG) is a multifunctional angiogenic protein that participates in both normal development and diseases.
Abnormal serum ANG levels are commonly reported in various diseases.
However, whether ANG can serve as a diagnostic or prognostic marker for different diseases remains a matter of debate.
Methods.
Here, we performed a systematic review and meta-analysis of the literature utilizing PubMed, Web of Science, and Scopus search engines to identify all publications comparing plasma or serum ANG levels between patients with different diseases and healthy controls, as were studies evaluating circulating ANG levels in healthy populations, pregnant women, or other demographic populations.
Results.
This study demonstrated that the serum ANG concentration in healthy populations was 336.14 ± 142.83 ng/ml and remained relatively stable in different populations and regions.
We noted no significant differences in serum ANG levels between patients and healthy controls, except in cases in which patients suffered from cancer or cardiovascular diseases.
The serum ANG concentrations were significantly higher in patients who developed colorectal cancer, acute myeloid leukemia, multiple myeloma, myelodysplastic syndromes, and heart failure than those in healthy controls.
Conclusion.
ANG has the potential of being a serum biomarker for cancers and cardiovascular diseases.
American Psychological Association (APA)
Yu, Dongdong& Cai, Yikai& Zhou, Wei& Sheng, Jinghao& Xu, Zhengping. 2018. The Potential of Angiogenin as a Serum Biomarker for Diseases: Systematic Review and Meta-Analysis. Disease Markers،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1153135
Modern Language Association (MLA)
Yu, Dongdong…[et al.]. The Potential of Angiogenin as a Serum Biomarker for Diseases: Systematic Review and Meta-Analysis. Disease Markers No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1153135
American Medical Association (AMA)
Yu, Dongdong& Cai, Yikai& Zhou, Wei& Sheng, Jinghao& Xu, Zhengping. The Potential of Angiogenin as a Serum Biomarker for Diseases: Systematic Review and Meta-Analysis. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1153135
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153135