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Molecular Targets and Associated Potential Pathways of Danlu Capsules in Hyperplasia of Mammary Glands Based on Systems Pharmacology
Joint Authors
Zheng, Qing-shan
He, Yingchun
Huang, Jihan
Tang, Haitao
Cao, Sumin
Wang, Kun
Feng, Yibin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hyperplasia of mammary glands (HMG) is common in middle-aged women.
Danlu capsules (DLCs) can effectively relieve pain and improve clinical symptoms and are safe for treating HMG.
However, the active substances in DLCs and the molecular mechanisms of DLCs in HMG remain unclear.
This study identified the bioactive compounds and delineated the molecular targets and potential pathways of DLCs by using a systems pharmacology approach.
The candidate compounds were retrieved from the traditional Chinese medicine systems pharmacology (TCMSP) database and analysis platform.
Each candidate’s druggability was analyzed according to its oral bioavailability and drug-likeness indices.
The candidate proteins and genes were extracted in the TCMSP and UniProt Knowledgebase, respectively.
The potential pathways associated with the genes were identified by performing gene enrichment analysis with DAVID Bioinformatics Resources 6.7.
A total of 603 compounds were obtained from DLCs, and 39 compounds and 66 targets associated with HMG were obtained.
Gene enrichment analysis yielded 10 significant pathways with 34 targets.
The integrated HMG pathway revealed that DLCs probably act in patients with HMG through multiple mechanisms of anti-inflammation, analgesic effects, and hormonal regulation.
This study provides novel insights into the mechanisms of DLCs in HMG, from the molecular level to the pathway level.
American Psychological Association (APA)
Huang, Jihan& Tang, Haitao& Cao, Sumin& He, Yingchun& Feng, Yibin& Wang, Kun…[et al.]. 2017. Molecular Targets and Associated Potential Pathways of Danlu Capsules in Hyperplasia of Mammary Glands Based on Systems Pharmacology. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153155
Modern Language Association (MLA)
Huang, Jihan…[et al.]. Molecular Targets and Associated Potential Pathways of Danlu Capsules in Hyperplasia of Mammary Glands Based on Systems Pharmacology. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153155
American Medical Association (AMA)
Huang, Jihan& Tang, Haitao& Cao, Sumin& He, Yingchun& Feng, Yibin& Wang, Kun…[et al.]. Molecular Targets and Associated Potential Pathways of Danlu Capsules in Hyperplasia of Mammary Glands Based on Systems Pharmacology. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153155