Serum Procalcitonin Levels in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion
Joint Authors
Tsukahara, Kohei
Fujii, Yosuke
Yashiro, Masato
Yamada, Mutsuko
Kikkawa, Tomonobu
Nosaka, Nobuyuki
Saito, Yukie
Ikeda, Masanori
Morishima, Tsuneo
Tsukahara, Hirokazu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Procalcitonin (PCT) is used as a biomarker in severe infections.
Here, we retrospectively investigated levels of serum PCT, C-reactive protein (CRP), and inflammatory cytokines (IL-6, TNF-α, and IFN-γ) in the second phase of patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD).
Nine AESD pediatric patients (4 men, 5 women; AESD group) admitted to Okayama University Hospital from 2010 to 2016 were compared with 10 control patients with febrile seizures (FS) (3 men, 7 women; FS group).
Mean PCT concentrations (ng/mL) in the AESD and FS groups were significantly different, at 9.8 ± 6.7 and 0.8 ± 0.9, respectively (p=0.0006).
CRP (mg/dL) were 0.79 ± 0.89 and 1.4 ± 1.0 (p=0.94), respectively; IL-6 (pg/mL) were 449.7 ± 705.0 and 118.3 ± 145.4 (p=0.20), respectively; TNF-α (pg/mL) were 18.6 ± 12.5 and 16.6 ± 6.0 (p=0.67), respectively; and IFN-γ (pg/mL) were 79.6 ± 158.5 and 41.9 ± 63.7 (p=0.56), respectively.
Ratios of PCT to CRP were 27.5 ± 34.2 and 3.2 ± 6.8 (p<0.0001), respectively.
The sensitivity and specificity in the diagnosis of AESD using a cutoff of PCT/CRP ratio of 1.0 were 79% and 100%, respectively.
These results suggest that PCT and the PCT/CRP ratio are useful in auxiliary diagnosis of the second stage of AESD, and in AESD, PCT is likely to increase through a different mechanism.
American Psychological Association (APA)
Fujii, Yosuke& Yashiro, Masato& Yamada, Mutsuko& Kikkawa, Tomonobu& Nosaka, Nobuyuki& Saito, Yukie…[et al.]. 2018. Serum Procalcitonin Levels in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion. Disease Markers،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1153158
Modern Language Association (MLA)
Fujii, Yosuke…[et al.]. Serum Procalcitonin Levels in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion. Disease Markers No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1153158
American Medical Association (AMA)
Fujii, Yosuke& Yashiro, Masato& Yamada, Mutsuko& Kikkawa, Tomonobu& Nosaka, Nobuyuki& Saito, Yukie…[et al.]. Serum Procalcitonin Levels in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1153158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153158