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A Preliminary Study of microRNA-208b after Acute Myocardial Infarction: Impact on 6-Month Survival
Joint Authors
Adcock, Ian M.
Alipoor, Shamila D.
Garssen, J.
Movassaghi, Mehrnaz
Alavi-Moghaddam, Mostafa
Chehrazi, Mohammad
Mohammadi, Maryam
Baratloo, Alireza
Mahjoub, Mohammad Parsa
Mortaz, Esmaeil
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
miRNAs contribute to a variety of essential biological processes including development, proliferation, differentiation, and apoptosis.
Circulating microRNAs are very stable and have shown potential as biomarkers of cardiovascular disease.
microRNA-208b expression was increased in the blood of patients with acute myocardial infarction (AMI) and has been proposed as a biomarker for early diagnosis.
In this pilot study, we investigate the potential of circulating miR-208b as a prognostic biomarker of 6-month survival in AMI patients.
Methods.
Plasma samples from 21 patients and 8 age- and gender-matched healthy adults were collected, and circulating levels of miR-208b were detected using quantitative real-time PCR.
Results.
miR-208b levels were higher in healthy control subjects (9.6-fold; P≤0.05).
Within the AMI patients, the levels of miR-208b were significantly lower in the survivor versus nonsurvivor group (fold change = 6.51 and 14.1, resp.; P≤0.05).
The Kaplan-Meier curve revealed that the 6-month survival time was significantly higher among AMI patients with a relative expression of miR-208b lower than 12.38.
The hazard ratio (HR) for the relative expression of miR-208b (<12.38 was the reference) was 5.08 (95% CI: 1.13–22.82; P=0.03).
Conclusion.
Our results showed that elevated miR-208b expression was associated with reduced long-term survival in AMI patients.
These pilot data indicate the need for a large follow-up study to confirm whether miR-208b can be used as a predictor of 6-month survival time after AMI.
American Psychological Association (APA)
Alavi-Moghaddam, Mostafa& Chehrazi, Mohammad& Alipoor, Shamila D.& Mohammadi, Maryam& Baratloo, Alireza& Mahjoub, Mohammad Parsa…[et al.]. 2018. A Preliminary Study of microRNA-208b after Acute Myocardial Infarction: Impact on 6-Month Survival. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153161
Modern Language Association (MLA)
Alavi-Moghaddam, Mostafa…[et al.]. A Preliminary Study of microRNA-208b after Acute Myocardial Infarction: Impact on 6-Month Survival. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153161
American Medical Association (AMA)
Alavi-Moghaddam, Mostafa& Chehrazi, Mohammad& Alipoor, Shamila D.& Mohammadi, Maryam& Baratloo, Alireza& Mahjoub, Mohammad Parsa…[et al.]. A Preliminary Study of microRNA-208b after Acute Myocardial Infarction: Impact on 6-Month Survival. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153161