Increased Cytokeratin 19 Fragment Levels Are Positively Correlated with Adenosine Deaminase Activity in Malignant Pleural Effusions from Adenocarcinomas
Joint Authors
Araujo, E. G.
Barillo, Jorge Luiz
da Silva Junior, Cyro Teixeira
Silva, Patricia Siqueira
de Souza, Joeber Bernardo Soares
Kanaan, Salim
Xavier, Analucia Rampazzo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Adenosine deaminase (ADA) and cytokeratin 19 (CK19) are known pleural biomarkers.
Although ADA in humans functions mainly in the immune system, it also appears to be associated with the differentiation of epithelial cells.
Keratin filaments are important structural stabilizers of epithelial cells and potent biomarkers in epithelial differentiation.
This study aimed to investigate the simultaneous presence of the ADA enzyme and CK19 fragments to assess epithelial differentiation in malignant and benign pleural fluids.
Diagnosis of the cause of pleural effusion syndrome was confirmed by means of standard examinations and appropriate surgical procedures.
An ADA assay, in which ADA irreversibly catalyzes the conversion of adenosine into inosine, was performed using a commercial kit.
The CK19 assay was performed using a CYFRA 21-1 kit, developed to detect quantitative soluble fragments of CK19 using an electrochemiluminescence immunoassay.
One hundred nineteen pleural fluid samples were collected from untreated individuals with pleural effusion syndrome due to several causes.
ADA levels only correlated with CK19 fragments in adenocarcinomas, with high significance and good correlation (rho = 0.5145, P=0.0036).
However, further studies are required to understand this strong association on epithelial differentiation in metastatic pleural fluids from adenocarcinomas.
American Psychological Association (APA)
Barillo, Jorge Luiz& da Silva Junior, Cyro Teixeira& Silva, Patricia Siqueira& de Souza, Joeber Bernardo Soares& Kanaan, Salim& Xavier, Analucia Rampazzo…[et al.]. 2018. Increased Cytokeratin 19 Fragment Levels Are Positively Correlated with Adenosine Deaminase Activity in Malignant Pleural Effusions from Adenocarcinomas. Disease Markers،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153173
Modern Language Association (MLA)
Barillo, Jorge Luiz…[et al.]. Increased Cytokeratin 19 Fragment Levels Are Positively Correlated with Adenosine Deaminase Activity in Malignant Pleural Effusions from Adenocarcinomas. Disease Markers No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1153173
American Medical Association (AMA)
Barillo, Jorge Luiz& da Silva Junior, Cyro Teixeira& Silva, Patricia Siqueira& de Souza, Joeber Bernardo Soares& Kanaan, Salim& Xavier, Analucia Rampazzo…[et al.]. Increased Cytokeratin 19 Fragment Levels Are Positively Correlated with Adenosine Deaminase Activity in Malignant Pleural Effusions from Adenocarcinomas. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153173