Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies
Joint Authors
Song, Jinlin
Li, Yao
Feng, Ge
Deng, Yuejia
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Introduction.
The association between interleukin-10- (IL-10-) 592 (-590, -597) C>A polymorphisms and susceptibility to chronic or aggressive periodontitis (CP or AgP) is conflicting.
This meta-analysis is aimed at quantitatively estimating the association.
Materials and Methods.
PubMed, Embase, Web of Science, and WANFAN were searched for studies performed prior to January 31, 2018, to collect data for our research.
Meta-analysis was performed using RevMan 5.3 or STATA 14.0.
Results.
In total, 18 studies that met our criteria were included.
Overall or HWE subgroup analysis of individuals with this polymorphism revealed that in terms of CP susceptibility, there was a significant difference between case groups and control groups in the A allele versus C allele model (OR = 1.38, 95% CI = 1.17–1.64 or OR = 1.38, 95% CI = 1.12–1.70), in the AA versus CC+CA model (OR = 1.49, 95% CI =1.06–2.10 or OR = 1.42, 95% CI = 1.13–1.78), and in the CC versus CA+AA model (OR = 0.69, 95% CI = 0.51–0.92 or OR = 0.68, 95% CI = 0.49–0.93); subgroup analysis based on a nonsmoking population also displayed significance in the A allele versus C allele model (OR = 1.43, 95% CI = 1.15–1.79) and CC versus CA+AA model (OR = 0.62, 95% CI = 0.44–0.87).
For this polymorphisms and AgP susceptibility, our analyses revealed a significant association in both the A allele versus C allele model (OR = 1.29, 95% CI = 1.01–1.63) and the AA versus CC+CA model (OR = 1.93, 95% CI = 1.30–2.89); subgroup analysis based on Caucasian or nonsmoking populations showed significant differences in the AA versus CC+CA model (OR = 6.29, 95% CI = 1.78–22.21 or OR = 3.24, 95% CI = 1.59–6.61).
Conclusions.
IL-10-592 (-590, -597) A allele and the associated AA genotype may be risk factors for the onset of CP or AgP—particularly for the AA genotype and the increased risk of AgP in Caucasian or nonsmoking populations.
Conversely, the CC genotype may act as a protective factor against the onset of CP.
American Psychological Association (APA)
Li, Yao& Feng, Ge& Deng, Yuejia& Song, Jinlin. 2018. Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies. Disease Markers،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1153176
Modern Language Association (MLA)
Li, Yao…[et al.]. Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies. Disease Markers No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1153176
American Medical Association (AMA)
Li, Yao& Feng, Ge& Deng, Yuejia& Song, Jinlin. Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1153176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153176