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Association between MnSOD Val16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls
Joint Authors
Wang, Ping
Xi, Shoumin
Zhu, Yanfeng
Li, Sanqiang
Zhang, Yanle
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-02
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Manganese superoxide dismutase (MnSOD) plays a critical role in the defense against reactive oxygen species.
The association between MnSOD Val16Ala polymorphism and cancer risk has been widely studied, but the results are contradictory.
To obtain more precision on the association, we performed the current meta-analysis with 33,098 cases and 37,831 controls from 88 studies retrieved from PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases.
Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of association.
We found that the polymorphism was associated with an increased overall cancer risk (homozygous: OR=1.09, 95% CI = 1.00–1.19; heterozygous: OR=1.07, 95% CI = 1.02–1.12; dominant: OR=1.08, 95% CI = 1.02–1.14; and allele comparison: OR=1.06, 95% CI = 1.02–1.11).
Stratification analysis further showed an increased risk for prostate cancer, Asians, Caucasians, population-based studies, hospital-based studies, low quality and high quality studies.
However, the increased risk for MnSOD Val16Ala polymorphism among Asians needs further validation based on the false-positive report probability (FPRP) test.
To summarize, this meta-analysis suggests that the MnSOD Val16Ala polymorphism is associated with significantly increased cancer risk, which needs further validation in single large studies.
American Psychological Association (APA)
Wang, Ping& Zhu, Yanfeng& Xi, Shoumin& Li, Sanqiang& Zhang, Yanle. 2018. Association between MnSOD Val16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls. Disease Markers،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1153205
Modern Language Association (MLA)
Wang, Ping…[et al.]. Association between MnSOD Val16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls. Disease Markers No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1153205
American Medical Association (AMA)
Wang, Ping& Zhu, Yanfeng& Xi, Shoumin& Li, Sanqiang& Zhang, Yanle. Association between MnSOD Val16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1153205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153205