The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker
Joint Authors
Jing, Wei
Zhu, Man
Zhang, Xian-wei
Zhou, Hu
Qiu, Shi-li
Liang, Chun-zi
Tu, Jian-cheng
Yu, Mingxia
Luo, Ping
Liu, Xuefang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Circular RNAs (circRNA), a class of noncoding RNAs, have been found to be involved in various diseases.
Here, the expression levels of the circRNA hsa_circ_0001445 in 73 pairs of hepatocellular carcinoma (HCC) and adjacent nontumor tissues were investigated by quantitative real-time polymerase chain reaction (qRT-PCR).
Our data demonstrate that the hsa_circ_0001445 levels were significantly decreased in HCC tissues (P<0.001) and markedly associated with the number of tumor foci (P=0.014).
Furthermore, in vitro approaches showed that overexpression of hsa_circ_0001445 promoted apoptosis and inhibited proliferation, migration, and invasion of HCC-derived cells, suggesting that hsa_circ_0001445 might be involved in the development of HCC.
In addition, we found that the plasma hsa_circ_0001445 transcription levels in HCC patients were lower than those in cirrhosis (P<0.001) and hepatitis B (P<0.001) patients as well as in healthy controls (P<0.001).
In fact, receiver operating characteristic curve analysis indicated that plasma hsa_circ_0001445 could be a fairly accurate marker to distinguish HCC cases from healthy controls as well as patients with cirrhosis or hepatitis B.
American Psychological Association (APA)
Zhang, Xian-wei& Zhou, Hu& Jing, Wei& Luo, Ping& Qiu, Shi-li& Liu, Xuefang…[et al.]. 2018. The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker. Disease Markers،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153207
Modern Language Association (MLA)
Zhang, Xian-wei…[et al.]. The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker. Disease Markers No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1153207
American Medical Association (AMA)
Zhang, Xian-wei& Zhou, Hu& Jing, Wei& Luo, Ping& Qiu, Shi-li& Liu, Xuefang…[et al.]. The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153207
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153207