Pharmacological Basis for Use of Selaginella moellendorffii in Gouty Arthritis: Antihyperuricemic, Anti-Inflammatory, and Xanthine Oxidase Inhibition
Joint Authors
Li, Juan
Chen, Keli
Zhao, Ping
Zhang, Guo-li
Deng, Guang-rui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study was aimed at evaluating the effects of Selaginella moellendorffii Hieron.
(SM) on gouty arthritis and getting an insight of the possible mechanisms.
HPLC method was developed for chemical analysis.
The paw oedema, the neutrophil accumulation, inflammatory mediators, lipid peroxidation, and histopathological changes of the joints were analyzed in gouty arthritis rat model, and the kidney injury and serum urate were detected in hyperuricemic mice.
Pharmacokinetic result demonstrated that the main apigenin glycosides might be quantitatively transformed into apigenin in the mammalian body.
Among these compounds, the apigenin exhibited the strongest effect on xanthine oxidase (XOD).
SM aqueous extract has proved to be active in reducing hyperuricemia in dose-dependent manner, and the levels of blood urea nitrogen (BUN) and creatinine (Cr) in high dose group were decreased significantly as compared with hyperuricemic control group (P<0.01).
The high dose of SM extract could significantly prevent the paw swelling, reduce gouty joint inflammatory features, reduce the release of IL-1β and TNF-α, lower malondialdehyde (MDA) and myeloperoxidase (MPO) levels, and increase superoxide dismutase (SOD) level (P<0.01).
For the first time, this study provides a rational basis for the traditional use of SM aqueous extract against gout in folk medicine.
American Psychological Association (APA)
Zhao, Ping& Chen, Keli& Zhang, Guo-li& Deng, Guang-rui& Li, Juan. 2017. Pharmacological Basis for Use of Selaginella moellendorffii in Gouty Arthritis: Antihyperuricemic, Anti-Inflammatory, and Xanthine Oxidase Inhibition. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153211
Modern Language Association (MLA)
Zhao, Ping…[et al.]. Pharmacological Basis for Use of Selaginella moellendorffii in Gouty Arthritis: Antihyperuricemic, Anti-Inflammatory, and Xanthine Oxidase Inhibition. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153211
American Medical Association (AMA)
Zhao, Ping& Chen, Keli& Zhang, Guo-li& Deng, Guang-rui& Li, Juan. Pharmacological Basis for Use of Selaginella moellendorffii in Gouty Arthritis: Antihyperuricemic, Anti-Inflammatory, and Xanthine Oxidase Inhibition. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153211