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Atractylodin Induces Myosin Light Chain Phosphorylation and Promotes Gastric Emptying through Ghrelin Receptor
Joint Authors
Xu, Jian Ya
Bai, Yu
Zhao, Yan-hua
Yu, Xi-zhong
Hu, Yun-xia
Zhao, Zhi-qiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Atractylodin is one of the main constituents in the rhizomes of Atractylodes lancea Thunb., being capable of treating cancer cachexia-anorexia and age-related diseases as an agonist of growth hormone secretagogue receptor (GHSR).
GHSR was herein expressed in human gastric smooth muscle cells (HGSMCs) and activated by ghrelin receptor agonist L-692,585.
Like L-692,585, atractylodin also increased Ca2+ and enhanced the phosphorylation of myosin light chain (MLC) through GHSR in HGSMCs.
In addition, atractylodin promoted gastric emptying and MLC phosphorylation in the gastric antrum of mice also through GHSR.
Collectively, atractylodin can activate GHSR in gastric smooth muscle, as a potential target in clinical practice.
American Psychological Association (APA)
Bai, Yu& Zhao, Yan-hua& Xu, Jian Ya& Yu, Xi-zhong& Hu, Yun-xia& Zhao, Zhi-qiang. 2017. Atractylodin Induces Myosin Light Chain Phosphorylation and Promotes Gastric Emptying through Ghrelin Receptor. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153230
Modern Language Association (MLA)
Bai, Yu…[et al.]. Atractylodin Induces Myosin Light Chain Phosphorylation and Promotes Gastric Emptying through Ghrelin Receptor. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153230
American Medical Association (AMA)
Bai, Yu& Zhao, Yan-hua& Xu, Jian Ya& Yu, Xi-zhong& Hu, Yun-xia& Zhao, Zhi-qiang. Atractylodin Induces Myosin Light Chain Phosphorylation and Promotes Gastric Emptying through Ghrelin Receptor. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153230