Identification of Common Genes Refers to Colorectal Carcinogenesis with Paired Cancer and Noncancer Samples
Joint Authors
Tan, Zhi-Rong
Zhou, Hong-Hao
Zhang, Lihua
Cheng, Yu
Yang, Yonglong
Cheng, Lin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Colorectal cancer is a malignant tumor which harmed human beings’ health.
The aim of this study was to explore common biomarkers associated with colorectal carcinogenesis in paired cancer and noncancer samples.
At first, fifty-nine pairs of colorectal cancer and noncancer samples from three gene expression datasets were collected and analyzed.
Then, 181 upregulation and 282 downregulation common differential expression genes (DEGs) were found.
Next, functional annotation was performed in the DAVID database with the DEGs.
Finally, real-time polymerase chain reaction (PCR) assay was conducted to verify the analyses in sixteen colorectal cancer and individual-matched adjacent mucosa samples.
Real-time PCR showed that MCM2, RNASEH2A, and TOP2A were upregulated in colorectal cancer compared with adjacent mucosa samples (MCM2, P<0.001; RNASEH2A, P<0.001; TOP2A, P=0.001).
These suggested that 463 DEGs might contribute to colorectal carcinogenesis.
American Psychological Association (APA)
Zhang, Lihua& Yang, Yonglong& Cheng, Lin& Cheng, Yu& Zhou, Hong-Hao& Tan, Zhi-Rong. 2018. Identification of Common Genes Refers to Colorectal Carcinogenesis with Paired Cancer and Noncancer Samples. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153243
Modern Language Association (MLA)
Zhang, Lihua…[et al.]. Identification of Common Genes Refers to Colorectal Carcinogenesis with Paired Cancer and Noncancer Samples. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153243
American Medical Association (AMA)
Zhang, Lihua& Yang, Yonglong& Cheng, Lin& Cheng, Yu& Zhou, Hong-Hao& Tan, Zhi-Rong. Identification of Common Genes Refers to Colorectal Carcinogenesis with Paired Cancer and Noncancer Samples. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153243