Assessment of the Relationship between Carotid Intima-Media Thickening and Early-Stage Diabetic Kidney Disease Coupled with Helicobacter pylori Infection

Abstract EN

Objective.

This study aimed to explore the associations between carotid intima-media thickness (CIMT) and early-stage diabetic kidney disease (DKD) coupled with Helicobacter pylori (H.

pylori) infection in type 2 diabetic patients.

Methods.

A cross-sectional study including 180 type 2 diabetic participants was conducted to explore the associations between CIMT and early-stage DKD coupled with H.

pylori infection, and a stepwise multivariate regression analysis evaluated the correlations of CIMT with clinical and serologic parameters.

Results.

The type 2 diabetic patients with early-stage DKD coupled with H.

pylori infections had the highest CIMT values.

Apolipoprotein B (ApoB), urine albumin/creatinine ratio (UACR), and interleukin-6 (IL-6) were independent predictors of CIMT.

Conclusions.

Early-stage DKD coupled with H.

pylori infection may synergistically lead to significant CIMT thickening in type 2 diabetic patients.

Additionally, ApoB, UACR, and IL-6 levels were important independent risk factors for increased CIMT.