Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome
Joint Authors
Qu, Zhihui
Gao, Pujun
Xiao, Qingfei
Zhao, Ying
Yang, Liming
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inflammation is a complex response to diverse pathological conditions, resulting in negative rather than protective effects when uncontrolled.
Orientin (Ori), a flavonoid component isolated from natural plants, possesses abundant properties.
Thus, we aimed to discover the potential therapeutic effects of orientin on lipopolysaccharide- (LPS-) induced inflammation in RAW 264.7 cells and the underlying mechanisms.
In our studies, we evaluated the effects of Ori on proinflammatory mediator production stimulated by LPS, including tumor necrosis factor- (TNF-) α, interleukin- (IL-) 6, IL-18, and IL-1β, along with prostaglandin E2 (PGE2) and NO.
Our data indicated that orientin dramatically inhibited the levels of these mediators.
Consistent with these results, the expression levels of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were also reduced.
Further study demonstrated that such inhibitory effects of Ori were due to suppression of the nuclear factor-kappa B (NF-κB) pathway and nucleotide-binding domain- (NOD-) like receptor protein 3 (NLRP3) inflammasome activation, which may contribute to its anti-inflammatory effects.
Together, these findings show that Ori may be an effective candidate for ameliorating LPS-induced inflammatory responses.
American Psychological Association (APA)
Xiao, Qingfei& Qu, Zhihui& Zhao, Ying& Yang, Liming& Gao, Pujun. 2017. Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153270
Modern Language Association (MLA)
Xiao, Qingfei…[et al.]. Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153270
American Medical Association (AMA)
Xiao, Qingfei& Qu, Zhihui& Zhao, Ying& Yang, Liming& Gao, Pujun. Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153270