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Anti-Inflammatory Activity of the Essential Oil Citral in Experimental Infection with Staphylococcus aureus in a Model Air Pouch
Joint Authors
Timenetsky, Jorge
Miranda Marques, Lucas
Martins, Hellen Braga
Selis, Nathan das Neves
Souza, Clarissa Leal Silva e
Nascimento, Flávia S.
Carvalho, Suzi Pacheco de
Gusmão, Lorena D’Oliveira
Nascimento, Jannine dos Santos
Brito, Anne Karoline Pereira
Souza, Samira Itana de
Oliveira, Marcio Vasconcelos de
Yatsuda, Regiane
Uetanabaro, Ana Paula Trovatti
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study proposes to implement an alternative and effective strategy for local treatment of disease provoked by S.
aureus.
For the analysis of possible anti-inflammatory activity of essential oil, after establishing an air pouch model, 48 male mice of Balb/c were treated, infected, and euthanized at 4 and 8 h.
Thus, the total and differential white blood cells were counted in the animal’s blood, and cytokines IL-1β, IL-6, and TNF-α were titrated using ELISA in the air pouch lavage.
Moreover, TNF-α, IL-1β, and IL-6 gene expression was analyzed through an RT-qPCR array, and S.
aureus was quantified using qPCR.
Our results, p<0.05, showed that EOC reduced the quantity of microorganisms.
The group of mice treated with essential oil citral showed a significant decrease in TNF-α levels in tests demonstrating anti-inflammatory activity.
There is no data about the mutual influence of the air pouch model, essential oil citral, and S.
aureus.
Thus, considering the interaction of these variables and the anti-inflammatory activity of the essential oil citral, we demonstrated, by alternative local treatment, a new antimicrobial agent that is not an antibiotic.
American Psychological Association (APA)
Martins, Hellen Braga& Selis, Nathan das Neves& Souza, Clarissa Leal Silva e& Nascimento, Flávia S.& Carvalho, Suzi Pacheco de& Gusmão, Lorena D’Oliveira…[et al.]. 2017. Anti-Inflammatory Activity of the Essential Oil Citral in Experimental Infection with Staphylococcus aureus in a Model Air Pouch. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153277
Modern Language Association (MLA)
Martins, Hellen Braga…[et al.]. Anti-Inflammatory Activity of the Essential Oil Citral in Experimental Infection with Staphylococcus aureus in a Model Air Pouch. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153277
American Medical Association (AMA)
Martins, Hellen Braga& Selis, Nathan das Neves& Souza, Clarissa Leal Silva e& Nascimento, Flávia S.& Carvalho, Suzi Pacheco de& Gusmão, Lorena D’Oliveira…[et al.]. Anti-Inflammatory Activity of the Essential Oil Citral in Experimental Infection with Staphylococcus aureus in a Model Air Pouch. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153277