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Mitochondrial T16189C Polymorphism Is Associated with Metabolic Syndrome in the Mexican Population
Joint Authors
Saldaña-Rivera, Elsa
Careaga-Castilla, Marissa Jaqueline
Olvera-Cárdenas, Giovani Daniel
Pérez-Soto, Elvia
Sánchez Monroy, Virginia
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Genetic factors, such as the mitochondrial DNA (mtDNA) T16189C polymorphism, have been associated with metabolic syndrome (MetS), but this association has not been studied in Mexico to date.
The aim of the present study was to determine whether this polymorphism contributes to MetS in the Mexican population.
We recruited 100 unrelated volunteer subjects who were divided into 2 groups: with MetS (MetS group) and without MetS (control group).
All subjects were genotyped for the mtDNA T16189C polymorphism by polymerase chain reaction and sequencing.
The mitochondrial T16189C polymorphism was detected in 24 (24%) of 100 subjects analyzed.
The frequency of the mtDNA T16189C polymorphism was higher in the MetS group with 21 (32.3%) of 65 testing positive compared to 3 (8.5%) of 35 in the control group, indicating that this polymorphism is a probable risk factor for MetS in the Mexican population (odds ratio 5.0909, 95% CI 1.3977–18.5424, P=0.0136).
Our results may contribute to early diagnosis of MetS, which is essential for establishing changes in early stages of the disease to avoid further complications and pathologies, thereby preventing the development of type 2 diabetes and cardiovascular disease in Mexico.
American Psychological Association (APA)
Saldaña-Rivera, Elsa& Careaga-Castilla, Marissa Jaqueline& Olvera-Cárdenas, Giovani Daniel& Pérez-Soto, Elvia& Sánchez Monroy, Virginia. 2018. Mitochondrial T16189C Polymorphism Is Associated with Metabolic Syndrome in the Mexican Population. Disease Markers،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1153293
Modern Language Association (MLA)
Saldaña-Rivera, Elsa…[et al.]. Mitochondrial T16189C Polymorphism Is Associated with Metabolic Syndrome in the Mexican Population. Disease Markers No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1153293
American Medical Association (AMA)
Saldaña-Rivera, Elsa& Careaga-Castilla, Marissa Jaqueline& Olvera-Cárdenas, Giovani Daniel& Pérez-Soto, Elvia& Sánchez Monroy, Virginia. Mitochondrial T16189C Polymorphism Is Associated with Metabolic Syndrome in the Mexican Population. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1153293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153293