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Clinical Significance and Biological Role of HuR in Head and Neck Carcinomas
Joint Authors
Levidou, Georgia
Theocharis, Stamatios
Kotta-Loizou, Ioly
Tasoulas, Jason
Papadopoulos, Thomas
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Hu-antigen R (HuR) is a posttranscriptional regulator of several target mRNAs, implicated in carcinogenesis.
This review aims to present the current evidence regarding the biological role and potential clinical significance of HuR in head and neck carcinomas.
Methods.
The existing literature concerning HuR expression and function in head and neck carcinomas is critically presented and summarised.
Results.
HuR is expressed in the majority of the examined samples, showing higher cytoplasmic levels in malignant or premalignant cases.
Moreover, HuR modulates several genes implicated in biological processes important for malignant transformation, growth, and invasiveness.
HuR seems to be an adverse prognosticator in patients with OSCCs, whereas a correlation with a more aggressive phenotype is reported in several types of carcinomas.
Conclusions.
A consistent role of HuR in the carcinogenesis and progression of head and neck carcinomas is suggested; nevertheless, further studies are warranted to expand the present information.
American Psychological Association (APA)
Levidou, Georgia& Kotta-Loizou, Ioly& Tasoulas, Jason& Papadopoulos, Thomas& Theocharis, Stamatios. 2018. Clinical Significance and Biological Role of HuR in Head and Neck Carcinomas. Disease Markers،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1153299
Modern Language Association (MLA)
Levidou, Georgia…[et al.]. Clinical Significance and Biological Role of HuR in Head and Neck Carcinomas. Disease Markers No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1153299
American Medical Association (AMA)
Levidou, Georgia& Kotta-Loizou, Ioly& Tasoulas, Jason& Papadopoulos, Thomas& Theocharis, Stamatios. Clinical Significance and Biological Role of HuR in Head and Neck Carcinomas. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1153299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153299