The Ethanol Extract of Licorice (Glycyrrhiza uralensis) Protects against Triptolide-Induced Oxidative Stress through Activation of Nrf2
Joint Authors
Li, Huan-De
Yan, Miao
Cao, Ling-Juan
Li, Zhi-Hua
Fang, Ping-Fei
Zhang, Bi-Kui
Xiang, Daxiong
Hou, Zhen-Yan
Gong, Hui
Deng, Yang
Ma, Yan-Xia
Tang, Huai-Bo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
To investigate the potential role of nuclear factor erythroid 2-related factor 2 (Nrf2) in licorice ethanol extract (LEE) against triptolide- (TP-) induced hepatotoxicity, HepG2 cells were exposed to LEE (30, 60, and 90 mg·L−1) for 12 h and then treated with TP (50 nM) for 24 h.
Besides, an acute liver injury model was established in ICR mice by a single dose of TP (1.0 mg·kg−1, i.p.).
Relevant oxidant and antioxidant mediators were analyzed.
TP led to an obvious oxidative stress as evidenced by increasing levels of ROS and decreasing GSH contents in HepG2 cells.
In vitro results were likely to hold true in in vivo experiments.
LEE protected against TP-induced oxidative stress in both in vitro and in vivo conditions.
Furthermore, the decreased level of Nrf2 in the TP-treated group was observed.
The mRNA levels of downstream genes decreased as well in ICR mice liver, whereas they increased in HepG2 cells.
In contrast, LEE pretreatment significantly increased the level of Nrf2 and its downstream genes.
LEE protects against TP-induced oxidative stress partly via the activation of Nrf2 pathway.
American Psychological Association (APA)
Cao, Ling-Juan& Hou, Zhen-Yan& Li, Huan-De& Zhang, Bi-Kui& Fang, Ping-Fei& Xiang, Daxiong…[et al.]. 2017. The Ethanol Extract of Licorice (Glycyrrhiza uralensis) Protects against Triptolide-Induced Oxidative Stress through Activation of Nrf2. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153322
Modern Language Association (MLA)
Cao, Ling-Juan…[et al.]. The Ethanol Extract of Licorice (Glycyrrhiza uralensis) Protects against Triptolide-Induced Oxidative Stress through Activation of Nrf2. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1153322
American Medical Association (AMA)
Cao, Ling-Juan& Hou, Zhen-Yan& Li, Huan-De& Zhang, Bi-Kui& Fang, Ping-Fei& Xiang, Daxiong…[et al.]. The Ethanol Extract of Licorice (Glycyrrhiza uralensis) Protects against Triptolide-Induced Oxidative Stress through Activation of Nrf2. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153322