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Anticancer Effect of Nemopilema nomurai Jellyfish Venom on HepG2 Cells and a Tumor Xenograft Animal Model
Joint Authors
Bae, Seong Kyeong
Lee, Hyunkyoung
Kang, Changkeun
Kim, Euikyung
Kim, Munki
Pyo, Min Jung
Kim, Minkyung
Yang, Sujeoung
Won, Chung-kil
Yoon, Won Duk
Han, Chang Hoon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Various kinds of animal venoms and their components have been widely studied for potential therapeutic applications.
This study evaluated whether Nemopilema nomurai jellyfish venom (NnV) has anticancer activity.
NnV strongly induced cytotoxicity of HepG2 cells through apoptotic cell death, as demonstrated by alterations of chromatic morphology, activation of procaspase-3, and an increase in the Bax/Bcl-2 ratio.
Furthermore, NnV inhibited the phosphorylation of PI3K, PDK1, Akt, mTOR, p70S6K, and 4EBP1, whereas it enhanced the expression of p-PTEN.
Interestingly, NnV also inactivated the negative feedback loops associated with Akt activation, as demonstrated by downregulation of Akt at Ser473 and mTOR at Ser2481.
The anticancer effect of NnV was significant in a HepG2 xenograft mouse model, with no obvious toxicity.
HepG2 cell death by NnV was inhibited by tetracycline, metalloprotease inhibitor, suggesting that metalloprotease component in NnV is closely related to the anticancer effects.
This study demonstrates, for the first time, that NnV exerts highly selective cytotoxicity in HepG2 cells via dual inhibition of the Akt and mTOR signaling pathways, but not in normal cells.
American Psychological Association (APA)
Lee, Hyunkyoung& Bae, Seong Kyeong& Kim, Munki& Pyo, Min Jung& Kim, Minkyung& Yang, Sujeoung…[et al.]. 2017. Anticancer Effect of Nemopilema nomurai Jellyfish Venom on HepG2 Cells and a Tumor Xenograft Animal Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153324
Modern Language Association (MLA)
Lee, Hyunkyoung…[et al.]. Anticancer Effect of Nemopilema nomurai Jellyfish Venom on HepG2 Cells and a Tumor Xenograft Animal Model. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1153324
American Medical Association (AMA)
Lee, Hyunkyoung& Bae, Seong Kyeong& Kim, Munki& Pyo, Min Jung& Kim, Minkyung& Yang, Sujeoung…[et al.]. Anticancer Effect of Nemopilema nomurai Jellyfish Venom on HepG2 Cells and a Tumor Xenograft Animal Model. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153324
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153324