Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population
Joint Authors
Tomandl, Josef
Horak, Martin
Kuruczova, Daniela
Zlamal, Filip
Bienertova-Vasku, Julie
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Follistatin-like 1 (FSTL1) is a secreted adipomyokine with a possible link to obesity; however, its connection to extreme obesity currently remains unknown.
In order to analyze such association for the very first time, we employed a unique cohort of morbidly and super obese individuals with a mean BMI of 44.77 kg/m2 and measured the levels of circulating FSTL1.
We explored the 3′ UTR of FSTL1 to locate a genetic variant which impairs microRNA binding.
We located and investigated such SNP (rs1057231) in relation to the FSTL1 protein level, obesity status, and other body composition parameters.
We observed a significant decline in FSTL1 level in obese subjects in comparison to nonobese ones.
The evaluated SNP was found to correlate with FSTL1 only in nonobese subjects.
The presented results were not affected by sex since both males and females expressed FSTL1 equally.
We suggest that the FSTL1 decrease observed in extremely obese subjects is a result of adipogenesis reduction accompanied by a senescence of preadipocytes which otherwise willingly express FSTL1, increased adipocyte apoptosis, and epigenetic FSTL1 silencing.
American Psychological Association (APA)
Horak, Martin& Kuruczova, Daniela& Zlamal, Filip& Tomandl, Josef& Bienertova-Vasku, Julie. 2018. Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153331
Modern Language Association (MLA)
Horak, Martin…[et al.]. Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153331
American Medical Association (AMA)
Horak, Martin& Kuruczova, Daniela& Zlamal, Filip& Tomandl, Josef& Bienertova-Vasku, Julie. Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153331