Nesfatin-1Nucleobindin-2 Is a Potent Prognostic Marker and Enhances Cell Proliferation, Migration, and Invasion in Bladder Cancer
Joint Authors
Liu, Guang-Ming
Xu, Zi-Qiang
Ma, Hong-Shun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In recent researches, high expression of nesfatin-1/nucleobindin-2 (NUCB2) is linked to poor prognosis in prostate and colon cancer due to the enhancement in proliferation, migration, and invasion.
However, the role of nesfatin-1 in bladder cancer is not clear.
In this study, we examined the expression of NUCB2 in bladder cancer using immunohistochemistry and observed that its high expression was associated with recurrence and metastasis.
In addition, the transwell assay and wound healing assay showed that cell migration and invasion were decreased with NUCB2 knockdown in T24 and 5637 cells.
In vivo, tumor growth and metastasis were inhibited with shRNA treatment in T24 cells.
Those results showed that NUCB2 played an important role in bladder cancer and could be considered a potent prognostic factor in bladder cancer.
American Psychological Association (APA)
Liu, Guang-Ming& Xu, Zi-Qiang& Ma, Hong-Shun. 2018. Nesfatin-1Nucleobindin-2 Is a Potent Prognostic Marker and Enhances Cell Proliferation, Migration, and Invasion in Bladder Cancer. Disease Markers،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153334
Modern Language Association (MLA)
Liu, Guang-Ming…[et al.]. Nesfatin-1Nucleobindin-2 Is a Potent Prognostic Marker and Enhances Cell Proliferation, Migration, and Invasion in Bladder Cancer. Disease Markers No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1153334
American Medical Association (AMA)
Liu, Guang-Ming& Xu, Zi-Qiang& Ma, Hong-Shun. Nesfatin-1Nucleobindin-2 Is a Potent Prognostic Marker and Enhances Cell Proliferation, Migration, and Invasion in Bladder Cancer. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153334
