A Metabolomics-Based Strategy for the Mechanism Exploration of Traditional Chinese Medicine: Descurainia sophia Seeds Extract and Fractions as a Case Study
Joint Authors
Kuang, Haixue
Feng, Weisheng
Zheng, Xiaoke
Zhou, Ning
Sun, Ya-Ping
Wang, Qiu-Hong
Yang, Yan-Yun
Bai, Zhi-Yao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A UPLC-QTOF-MS based metabolomics research was conducted to explore potential biomarkers which would increase our understanding of the model and to assess the integral efficacy of Descurainia sophia seeds extract (DS-A).
Additionally, DS-A was split into five fractions in descending order of polarity, which were utilized to illustrate the mechanism together.
The 26 identified biomarkers were mainly related to disturbances in phenylalanine, tyrosine, tryptophan, purine, arginine, and proline metabolism.
Furthermore, heat map, hierarchical cluster analysis (HCA), and correlation network diagram of biomarkers perturbed by modeling were all conducted.
The results of heat map and HCA suggested that fat oil fraction could reverse the abnormal metabolism in the model to some extent; meanwhile the metabolic inhibitory effect produced by the other four fractions helped to relieve cardiac load and compensate the insufficient energy supplement induced by the existing heart and lung injury in model rats.
Briefly, the split fractions interfered with the model from different aspects and ultimately constituted the overall effects of extract.
In conclusion, the metabolomics method, combined with split fractions of extract, is a powerful approach for illustrating pathologic changes of Chinese medicine syndrome and action mechanisms of traditional Chinese medicine.
American Psychological Association (APA)
Zhou, Ning& Sun, Ya-Ping& Zheng, Xiaoke& Wang, Qiu-Hong& Yang, Yan-Yun& Bai, Zhi-Yao…[et al.]. 2017. A Metabolomics-Based Strategy for the Mechanism Exploration of Traditional Chinese Medicine: Descurainia sophia Seeds Extract and Fractions as a Case Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153341
Modern Language Association (MLA)
Zhou, Ning…[et al.]. A Metabolomics-Based Strategy for the Mechanism Exploration of Traditional Chinese Medicine: Descurainia sophia Seeds Extract and Fractions as a Case Study. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1153341
American Medical Association (AMA)
Zhou, Ning& Sun, Ya-Ping& Zheng, Xiaoke& Wang, Qiu-Hong& Yang, Yan-Yun& Bai, Zhi-Yao…[et al.]. A Metabolomics-Based Strategy for the Mechanism Exploration of Traditional Chinese Medicine: Descurainia sophia Seeds Extract and Fractions as a Case Study. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153341