Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of Coicis Semen and Artemisia capillaris for Precocious Puberty: A Preliminary Experimental Study Using Female Rats
Joint Authors
Kang, Ki Sung
Trinh, Tuy An
Park, Seung Chan
Oh, Jihong
Kim, Chang-Eop
Lee, Hye Lim
Yoo, Hwa-Seung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Precocious puberty is a common endocrine disease in children.
Inappropriate activation of hypothalamic–pituitary–gonadal axis leads to the development of secondary sexual characteristics at an earlier age than normal children and causes short stature in adulthood.
Objectives.
The aim of this study is to evaluate the preventive effects of a herbal formulation containing a mixture of Coicis Semen and Artemisia capillaris (hEIF extract) on precocious puberty.
Methods.
The preventive effect of hEIF extract on precocious puberty in rats was evaluated by measuring blood component after 3 weeks of treatment via oral administration.
Network pharmacological analyses were performed to predict the bioactive components of hEIF extract.
Results.
In vivo studies showed that hEIF extract significantly reduced follicle stimulating hormone (FSH) levels.
After treatment with 200 mg/kg of hEIF extract, the FSH level was 5.33±1.10 ng/mL, whereas the FSH level in the vehicle group was 46.73±0.80 ng/mL.
Moreover, the use of hEIF extract did not stimulate body growth and bone accretion in rats.
The network pharmacological analysis led to the identification of multiple targets of hEIF extract related to lipolysis and the female sex hormone-related pathways.
Conclusion.
hEIF extract can be used as an FSH inhibitor for the treatment of precocious puberty.
American Psychological Association (APA)
Trinh, Tuy An& Park, Seung Chan& Oh, Jihong& Kim, Chang-Eop& Kang, Ki Sung& Yoo, Hwa-Seung…[et al.]. 2017. Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of Coicis Semen and Artemisia capillaris for Precocious Puberty: A Preliminary Experimental Study Using Female Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153364
Modern Language Association (MLA)
Trinh, Tuy An…[et al.]. Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of Coicis Semen and Artemisia capillaris for Precocious Puberty: A Preliminary Experimental Study Using Female Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153364
American Medical Association (AMA)
Trinh, Tuy An& Park, Seung Chan& Oh, Jihong& Kim, Chang-Eop& Kang, Ki Sung& Yoo, Hwa-Seung…[et al.]. Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of Coicis Semen and Artemisia capillaris for Precocious Puberty: A Preliminary Experimental Study Using Female Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153364