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The Effects of Guizhi Gancao Decoction on Pressure Overload-Induced Heart Failure and Posttranslational Modifications of Tubulin in Mice
Joint Authors
Tian, Jing
Chen, Hui-hua
Zhang, Chen
Guo, Wei
Lu, Rong
Zhao, Pei
Xu, Ming
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Guizhi Gancao Decoction (GGD), a traditional Chinese medical recipe, has been widely used in the treatment of cardiovascular diseases in China for centuries.
The present study was carried out to determine whether GGD exerts direct protective effects against pressure overload-induced heart failure.
Moreover, we investigated whether GGD affects tubulin expression and posttranslational modifications.
We demonstrated that GGD ameliorated TAC caused cardiac hypertrophy by gravimetric and echocardiography analysis in C57BL/6 mice.
We found that GGD abrogated TAC-induced myocardium fibrosis by Masson’s staining and collagen volume fraction (CVF) analysis.
By using pressure-volume hemodynamic measurements, we found that GGD prevented TAC-induced cardiac systolic and diastolic dysfunction.
Immunoblotting and immunofluorescent analysis revealed that GGD abrogated TAC-induced detyrosination and acetylation abnormalities on microtubules.
Our present study demonstrated potential therapeutic effects of GGD against pressure overload-induced heart failure.
American Psychological Association (APA)
Chen, Hui-hua& Zhao, Pei& Tian, Jing& Guo, Wei& Xu, Ming& Zhang, Chen…[et al.]. 2017. The Effects of Guizhi Gancao Decoction on Pressure Overload-Induced Heart Failure and Posttranslational Modifications of Tubulin in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153375
Modern Language Association (MLA)
Chen, Hui-hua…[et al.]. The Effects of Guizhi Gancao Decoction on Pressure Overload-Induced Heart Failure and Posttranslational Modifications of Tubulin in Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153375
American Medical Association (AMA)
Chen, Hui-hua& Zhao, Pei& Tian, Jing& Guo, Wei& Xu, Ming& Zhang, Chen…[et al.]. The Effects of Guizhi Gancao Decoction on Pressure Overload-Induced Heart Failure and Posttranslational Modifications of Tubulin in Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153375