A Review of the Potential of Phytochemicals from Prunus africana (Hook f.) Kalkman Stem Bark for Chemoprevention and Chemotherapy of Prostate Cancer
Joint Authors
Lee, Jun-Hwan
Kang, Youngmin
Komakech, Richard
Omujal, Francis
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Prostate cancer remains one of the major causes of death worldwide.
In view of the limited treatment options for patients with prostate cancer, preventive and treatment approaches based on natural compounds can play an integral role in tackling this disease.
Recent evidence supports the beneficial effects of plant-derived phytochemicals as chemopreventive and chemotherapeutic agents for various cancers, including prostate cancer.
Prunus africana has been used for generations in African traditional medicine to treat prostate cancer.
This review examined the potential roles of the phytochemicals from P.
africana, an endangered, sub-Saharan Africa plant in the chemoprevention and chemotherapy of prostate cancer.
In vitro and in vivo studies have provided strong pharmacological evidence for antiprostate cancer activities of P.
africana-derived phytochemicals.
Through synergistic interactions between different effective phytochemicals, P.
africana extracts have been shown to exhibit very strong antiandrogenic and antiangiogenic activities and have the ability to kill tumor cells via apoptotic pathways, prevent the proliferation of prostate cancer cells, and alter the signaling pathways required for the maintenance of prostate cancer cells.
However, further preclinical and clinical studies ought to be done to advance and eventually use these promising phytochemicals for the prevention and chemotherapy of human prostate cancer.
American Psychological Association (APA)
Komakech, Richard& Kang, Youngmin& Lee, Jun-Hwan& Omujal, Francis. 2017. A Review of the Potential of Phytochemicals from Prunus africana (Hook f.) Kalkman Stem Bark for Chemoprevention and Chemotherapy of Prostate Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153412
Modern Language Association (MLA)
Komakech, Richard…[et al.]. A Review of the Potential of Phytochemicals from Prunus africana (Hook f.) Kalkman Stem Bark for Chemoprevention and Chemotherapy of Prostate Cancer. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153412
American Medical Association (AMA)
Komakech, Richard& Kang, Youngmin& Lee, Jun-Hwan& Omujal, Francis. A Review of the Potential of Phytochemicals from Prunus africana (Hook f.) Kalkman Stem Bark for Chemoprevention and Chemotherapy of Prostate Cancer. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153412