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Clinical Significance of Hemostatic Parameters in the Prediction for Type 2 Diabetes Mellitus and Diabetic Nephropathy
Joint Authors
Fei, Xianming
Wo, Mingyi
Pan, Lianlian
Ye, Yali
Bao, Danni
Zhu, Fengjiao
Cheng, Maoliang
Ni, Xiuwen
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
It would be important to predict type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN).
This study was aimed at evaluating the predicting significance of hemostatic parameters for T2DM and DN.
Plasma coagulation and hematologic parameters before treatment were measured in 297 T2DM patients.
The risk factors and their predicting power were evaluated.
T2DM patients without complications exhibited significantly different activated partial thromboplastin time (aPTT), platelet (PLT), and D-dimer (D-D) levels compared with controls (P<0.01).
Fibrinogen (FIB), PLT, and D-D increased in DN patients compared with those without complications (P<0.001).
Both aPTT and PLT were the independent risk factors for T2DM (OR: 1.320 and 1.211, P<0.01, resp.), and FIB and PLT were the independent risk factors for DN (OR: 1.611 and 1.194, P<0.01, resp.).
The area under ROC curve (AUC) of aPTT and PLT was 0.592 and 0.647, respectively, with low sensitivity in predicting T2DM.
AUC of FIB was 0.874 with high sensitivity (85%) and specificity (76%) for DN, and that of PLT was 0.564, with sensitivity (60%) and specificity (89%) based on the cutoff values of 3.15 g/L and 245 × 109/L, respectively.
This study suggests that hemostatic parameters have a low predicting value for T2DM, whereas fibrinogen is a powerful predictor for DN.
American Psychological Association (APA)
Pan, Lianlian& Ye, Yali& Wo, Mingyi& Bao, Danni& Zhu, Fengjiao& Cheng, Maoliang…[et al.]. 2018. Clinical Significance of Hemostatic Parameters in the Prediction for Type 2 Diabetes Mellitus and Diabetic Nephropathy. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153416
Modern Language Association (MLA)
Pan, Lianlian…[et al.]. Clinical Significance of Hemostatic Parameters in the Prediction for Type 2 Diabetes Mellitus and Diabetic Nephropathy. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153416
American Medical Association (AMA)
Pan, Lianlian& Ye, Yali& Wo, Mingyi& Bao, Danni& Zhu, Fengjiao& Cheng, Maoliang…[et al.]. Clinical Significance of Hemostatic Parameters in the Prediction for Type 2 Diabetes Mellitus and Diabetic Nephropathy. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153416