Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2PGE2-PI3KAKTGSK3ββ-Catenin Signaling Pathway
Joint Authors
Zou, Xi
Wu, Jian
Sun, Wei
Liu, Shen-lin
Wu, Ting-Ting
Zheng, Pei-Qiu
Ma, Nai-Xia
Ding, Xue-Lian
Weng, Lei
Liu, Yang-Qing
Pu, Wen-Xiu
Huang, Nan-Guang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-21
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
To explore the role of CWP in invasion and migration of gastric cancer cells and its underlying molecular mechanism, we performed the experiment in SGC-7901 cells both in vitro and in vivo.
In the cell experiment, we evaluated cell proliferation by MTT assay.
The results showed that CWP can inhibit the growth of SGC-7901 cells.
The influence on cell migration and invasion was detected by wound-healing and Transwell invasion assays.
The results showed that the abilities of invasion and migration are restrained in CWP group.
Western blot showed that CWP can decrease the expression of Cox-2 and inhibit the PI3K/AKT/GSK3β/β-catenin signaling pathway.
In the animal experiment, we observed that CWP had an inhibitory effect on the growth of xenograft tumors of nude mice.
IHC assay, ELISA, RT-PCR assay, and Western blot assay were used to test relevant cytokines of Cox-2/PGE2-PI3K/AKT/GSK3β/β-catenin pathway.
The results showed that CWP can suppress relevant cytokines of Cox-2/PGE2-PI3K/AKT/GSK3β/β-catenin pathway.
In conclusion, we suggest that CWP inhibits the invasion and metastasis of SGC-7901 cells via Cox-2/PGE2-PI3K/AKT/GSK3β/β-catenin signaling pathway.
American Psychological Association (APA)
Ma, Nai-Xia& Sun, Wei& Wu, Jian& Liu, Shen-lin& Weng, Lei& Liu, Yang-Qing…[et al.]. 2017. Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2PGE2-PI3KAKTGSK3ββ-Catenin Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1153418
Modern Language Association (MLA)
Ma, Nai-Xia…[et al.]. Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2PGE2-PI3KAKTGSK3ββ-Catenin Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1153418
American Medical Association (AMA)
Ma, Nai-Xia& Sun, Wei& Wu, Jian& Liu, Shen-lin& Weng, Lei& Liu, Yang-Qing…[et al.]. Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2PGE2-PI3KAKTGSK3ββ-Catenin Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1153418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153418
