Effect of Huayu Tongluo Herbs on Reduction of Proteinuria via Inhibition of Wntβ-Catenin Signaling Pathway in Diabetic Rats
Joint Authors
Fang, Jing
Chen, Zhiqiang
Bai, Lu
Huo, Beibei
Guo, Qian
Xu, Jing
Zhang, Jianghua
Zhang, Fenfang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The study investigated the expression of Wnt/β-catenin pathway in diabetic rats and the intervention effect of Huayu Tongluo herbs (HTH).
Ten rats were randomly selected as control group and the remaining rats were established as diabetic models.
The diabetic rats were randomly divided into model group and HTH treatment group.
The intervention was intragastric administration in all rats for 20 weeks.
At the end of every 4 weeks, fasting blood glucose and 24 h urinary total protein quantitatively were measured.
At the end of the 20th week, biochemical parameters and body weight were tested.
The kidney tissues were observed under light microscope and transmission electron microscopy.
We examined Wnt/beta-catenin signaling pathway key proteins and renal interstitial fibrosis related molecular markers expression.
The results showed that HTH could reduce urinary protein excretion and relieve renal pathological damage.
Wnt4, p-GSK3β (S9), and β-catenin expression were decreased in the signaling pathway, but GSK3β level was not changed by HTH in diabetic rats.
Furthermore, the expressions of TGF-β1 and ILK were decreased, but the level of E-cadherin was increased in diabetic rats after treatment with HTH.
This study demonstrated that HTH could inhibit the high expression of Wnt/β-catenin pathway in kidney of diabetic rats.
The effect might be one of the main ways to reduce urinary protein excretion.
American Psychological Association (APA)
Bai, Lu& Huo, Beibei& Chen, Zhiqiang& Guo, Qian& Xu, Jing& Fang, Jing…[et al.]. 2017. Effect of Huayu Tongluo Herbs on Reduction of Proteinuria via Inhibition of Wntβ-Catenin Signaling Pathway in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153430
Modern Language Association (MLA)
Bai, Lu…[et al.]. Effect of Huayu Tongluo Herbs on Reduction of Proteinuria via Inhibition of Wntβ-Catenin Signaling Pathway in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153430
American Medical Association (AMA)
Bai, Lu& Huo, Beibei& Chen, Zhiqiang& Guo, Qian& Xu, Jing& Fang, Jing…[et al.]. Effect of Huayu Tongluo Herbs on Reduction of Proteinuria via Inhibition of Wntβ-Catenin Signaling Pathway in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153430