Prognostic Value of Long Noncoding RNAs in Patients with Gastrointestinal Cancer: A Systematic Review and Meta-Analysis
Joint Authors
Kang, Weibiao
Zheng, Qiang
Lei, Jun
Chen, Changyu
Yu, Changjun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Gastrointestinal cancers (GICs) are a huge threat to human health, which mainly include esophageal, gastric, and colorectal cancers.
The purpose of this study was to clarify the prognostic value of long noncoding RNAs (lncRNAs) in GICs.
A total of 111 articles were included, and 13103 patients (3123 with esophageal cancer, 4972 with gastric cancer, and 5008 with colorectal cancer) were enrolled in this study.
The pooled hazard ratio (HR) values and corresponding 95% confidence interval (95% CI) of overall survival (OS) related to different lncRNA expressions in esophageal, gastric, colorectal, and gastrointestinal cancer patients were 1.92 (1.70–2.16), 1.96 (1.77–2.16), 2.10 (1.87–2.36), and 2.00 (1.87–2.13), respectively.
We have identified 74 lncRNAs which were associated closely with poor prognosis of GIC patients, including 58 significantly upregulated lncRNA expression and 16 significantly downregulated lncRNA expression.
In addition, 47 of the included studies revealed relative mechanisms and 12 of them investigated the correlation between lncRNAs and microRNAs.
Taken together, this meta-analysis supports that specific lncRNAs are significantly related to the prognosis of GIC patients and may serve as novel markers for predicting the prognosis of GIC patients.
Furthermore, lncRNAs may have a promising contribution to lncRNA-based targeted therapy and clinical decision-making in the future.
American Psychological Association (APA)
Kang, Weibiao& Zheng, Qiang& Lei, Jun& Chen, Changyu& Yu, Changjun. 2018. Prognostic Value of Long Noncoding RNAs in Patients with Gastrointestinal Cancer: A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1153434
Modern Language Association (MLA)
Kang, Weibiao…[et al.]. Prognostic Value of Long Noncoding RNAs in Patients with Gastrointestinal Cancer: A Systematic Review and Meta-Analysis. Disease Markers No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1153434
American Medical Association (AMA)
Kang, Weibiao& Zheng, Qiang& Lei, Jun& Chen, Changyu& Yu, Changjun. Prognostic Value of Long Noncoding RNAs in Patients with Gastrointestinal Cancer: A Systematic Review and Meta-Analysis. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1153434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153434