Effect of Tetramethylpyrazine on Atherosclerosis and SCAPSREBP-1c Signaling Pathway in ApoE−− Mice Fed with a High-Fat Diet
Joint Authors
Shang, Ju-Ju
Kang, Qunfu
Liu, Weihong
Zhou, Mingxue
Zhang, Ying
Ren, Pan
Li, Sinai
Li, Ping
Zhang, Lei
Gong, Yanbing
Liu, Hong-Xu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Lipid metabolism dysregulation plays a crucial role in the occurrence of atherosclerosis (As).
SCAP/SREBP signaling is the main pathway for regulating lipid metabolism.
Tetramethylpyrazine (TMP), a Traditional Chinese Medicine (TCM) for treating angina pectoris, has antiatherosclerotic effects and ameliorates blood lipids disturbance.
However, its precise mechanism remains unclear.
This study investigated the mechanism of TMP in ameliorating As in mice model.
After six weeks of high-fat diet, 30 ApoE−/− mice were randomized (n=10) and treated with Lipitor, TMP, or distilled water for six weeks.
The serum blood lipids and insulin levels were measured.
The expressions of PAQR3, Insig-1, SCAP, SREBP-1c, IRS-1, PI3K, Akt, and mTORC-1 in the adipose tissues were determined.
The results showed that TMP could significantly decrease blood lipids levels, insulin, and corrected plaque area of the ApoE−/− mice as compared to the untreated mice (P<0.05, P<0.01).
Moreover, TMP could significantly downregulate the expressions of SCAP, SREBP-1c, PAQR3, IRS-1, PI3K, Akt, and mTORC1 (P<0.01).
Thus, TMP may ameliorate lipid metabolism disorder and As by downregulating PAQR3 and inhibiting SCAP/SREBP-1c signaling pathway.
In addition, PI3K/Akt/mTORC1 signaling pathway may be involved in this process.
American Psychological Association (APA)
Zhang, Ying& Ren, Pan& Kang, Qunfu& Liu, Weihong& Li, Sinai& Li, Ping…[et al.]. 2017. Effect of Tetramethylpyrazine on Atherosclerosis and SCAPSREBP-1c Signaling Pathway in ApoE−− Mice Fed with a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153441
Modern Language Association (MLA)
Zhang, Ying…[et al.]. Effect of Tetramethylpyrazine on Atherosclerosis and SCAPSREBP-1c Signaling Pathway in ApoE−− Mice Fed with a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153441
American Medical Association (AMA)
Zhang, Ying& Ren, Pan& Kang, Qunfu& Liu, Weihong& Li, Sinai& Li, Ping…[et al.]. Effect of Tetramethylpyrazine on Atherosclerosis and SCAPSREBP-1c Signaling Pathway in ApoE−− Mice Fed with a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153441