Qiliqiangxin Enhances Cardiac Glucose Metabolism and Improves Diastolic Function in Spontaneously Hypertensive Rats
Joint Authors
Ge, Junbo
Wang, Yanyan
Fu, Mingqiang
Wang, Jingfeng
Zhang, Jingjing
Han, Xueting
Zhou, Jingmin
Li, Zhiming
Zhao, Weipeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cardiac diastolic dysfunction has emerged as a growing type of heart failure.
The present study aims to explore whether Qiliqiangxin (QL) can benefit cardiac diastolic function in spontaneously hypertensive rat (SHR) through enhancement of cardiac glucose metabolism.
Fifteen 12-month-old male SHRs were randomly divided into QL-treated, olmesartan-treated, and saline-treated groups.
Age-matched WKY rats served as normal controls.
Echocardiography and histological analysis were performed.
Myocardial glucose uptake was determined by 18F-FDG using small-animal PET imaging.
Expressions of several crucial proteins and key enzymes related to glucose metabolism were also evaluated.
As a result, QL improved cardiac diastolic function in SHRs, as evidenced by increased E′/A′and decreased E/E′ (P<0.01).
Meanwhile, QL alleviated myocardial hypertrophy, collagen deposits, and apoptosis (P<0.01).
An even higher myocardial glucose uptake was illustrated in QL-treated SHR group (P<0.01).
Moreover, an increased CS activity and ATP production was observed in QL-treated SHRs (P<0.05).
QL enhanced cardiac glucose utilization and oxidative phosphorylation in SHRs by upregulating AMPK/PGC-1α axis, promoting GLUT-4 expression, and regulating key enzymes related to glucose aerobic oxidation such as HK2, PDK4, and CS (P<0.01).
Our data suggests that QL improves cardiac diastolic function in SHRs, which may be associated with enhancement of myocardial glucose metabolism.
American Psychological Association (APA)
Wang, Jingfeng& Li, Zhiming& Wang, Yanyan& Zhang, Jingjing& Zhao, Weipeng& Fu, Mingqiang…[et al.]. 2017. Qiliqiangxin Enhances Cardiac Glucose Metabolism and Improves Diastolic Function in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153457
Modern Language Association (MLA)
Wang, Jingfeng…[et al.]. Qiliqiangxin Enhances Cardiac Glucose Metabolism and Improves Diastolic Function in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1153457
American Medical Association (AMA)
Wang, Jingfeng& Li, Zhiming& Wang, Yanyan& Zhang, Jingjing& Zhao, Weipeng& Fu, Mingqiang…[et al.]. Qiliqiangxin Enhances Cardiac Glucose Metabolism and Improves Diastolic Function in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153457