Goreisan Inhibits Upregulation of Aquaporin 4 and Formation of Cerebral Edema in the Rat Model of Juvenile Hypoxic-Ischemic Encephalopathy
Joint Authors
Ishii, Eiichi
Yano, Yoshiaki
Yano, Hajime
Takahashi, Hisaaki
Yoshimoto, Kouhei
Tsuda, Shinji
Fujiyama, Kenta
Izumo-Shimizu, Yusuke
Motoie, Ryota
Ito, Masanori
Tanaka, Junya
Fukuda, Mitsumasa
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Secondary cerebral edema regulation is of prognostic significance in hypoxic-ischemic encephalopathy (HIE), and aquaporin 4 (AQP4) plays an important role in the pathogenesis of cerebral edema.
The traditional Japanese herbal medicine Goreisan relieves brain edema in adults; however, its effect and pharmacological mechanism in children are unknown.
We investigated the effects of Goreisan on HIE-associated brain edema and AQP4 expression in a juvenile rat model, established by combined occlusion of middle cerebral and common carotid arteries.
Magnetic resonance imaging showed that the lesion areas were significantly smaller in the Goreisan- (2 g/kg) treated group than in the nontreated (saline) group at 24 and 48 h postoperatively.
AQP4 mRNA levels in the lesion and nonlesion sides were significantly suppressed in the Goreisan group compared with the nontreated group 36 h postoperatively.
Western blotting revealed that levels of AQP4 protein were significantly decreased in the Goreisan group compared with the nontreated group in the lesion side 72 h postoperatively, but not at 12 or 36 h.
After 14 days, the Goreisan group had a significantly better survival rate.
These findings suggest that Goreisan suppresses brain edema in HIE and improves survival in juvenile rats, possibly via regulation of AQP4 expression and function.
American Psychological Association (APA)
Yano, Yoshiaki& Yano, Hajime& Takahashi, Hisaaki& Yoshimoto, Kouhei& Tsuda, Shinji& Fujiyama, Kenta…[et al.]. 2017. Goreisan Inhibits Upregulation of Aquaporin 4 and Formation of Cerebral Edema in the Rat Model of Juvenile Hypoxic-Ischemic Encephalopathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153465
Modern Language Association (MLA)
Yano, Yoshiaki…[et al.]. Goreisan Inhibits Upregulation of Aquaporin 4 and Formation of Cerebral Edema in the Rat Model of Juvenile Hypoxic-Ischemic Encephalopathy. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153465
American Medical Association (AMA)
Yano, Yoshiaki& Yano, Hajime& Takahashi, Hisaaki& Yoshimoto, Kouhei& Tsuda, Shinji& Fujiyama, Kenta…[et al.]. Goreisan Inhibits Upregulation of Aquaporin 4 and Formation of Cerebral Edema in the Rat Model of Juvenile Hypoxic-Ischemic Encephalopathy. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153465