Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?
Joint Authors
Hennenlotter, Jörg
Schwentner, Christian
Todenhöfer, Tilman
Mohrhardt, Sarah
Rausch, Steffen
Bier, Simone
Maas, Moritz
Esser, Michael
Deininger, Susanne
Walz, Simon
Bedke, Jens
Stenzl, Arnulf
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
To assess the performance of urine markers determined in urine samples from the bladder compared to samples collected from the upper urinary tract (UUT) for diagnosis of UUT urothelial carcinoma (UC).
Patients and Methods.
The study comprised 758 urine samples either collected from the bladder (n=373) or UUT (n=385).
All patients underwent urethrocystoscopy and UUT imaging or ureterorenoscopy.
Cytology, fluorescence in situ hybridization (FISH), immunocytology (uCyt+), and nuclear matrix protein 22 (NMP22) were performed.
Results.
UUT UC was diagnosed in 59 patients (19.1%) (UUT urine) and 27 patients (7.2%) (bladder-derived urine).
For UUT-derived samples, sensitivities for cytology, FISH, NMP22, and uCyt+ were 74.6, 79.0, 100.0, and 100.0, while specificities were 66.6, 50.7, 5.9, and 66.7%, respectively.
In bladder-derived samples, sensitivities were 59.3, 52.9, 62.5, and 50.0% whereas specificities were 82.9, 85.0, 31.3, and 69.8%.
In UUT-derived samples, concomitant bladder cancer led to increased false-positive rates of cytology and FISH.
Conclusions.
Urine markers determined in urine collected from the UUT exhibit better sensitivity but lower specificity compared to markers determined in bladder-derived urine.
Concomitant or recent diagnosis of UC of the bladder can further influence markers determined in UUT urine.
American Psychological Association (APA)
Bier, Simone& Hennenlotter, Jörg& Esser, Michael& Mohrhardt, Sarah& Rausch, Steffen& Schwentner, Christian…[et al.]. 2018. Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?. Disease Markers،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1153466
Modern Language Association (MLA)
Bier, Simone…[et al.]. Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?. Disease Markers No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1153466
American Medical Association (AMA)
Bier, Simone& Hennenlotter, Jörg& Esser, Michael& Mohrhardt, Sarah& Rausch, Steffen& Schwentner, Christian…[et al.]. Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1153466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153466