A Novel Technique of Spectral Discrimination of Variants of Sickle Cell Anemia

Joint Authors

AlSalhi, M. S.
Masilamani, Vadivel
Devanesan, Sandanasamy
AlQathani, Fatma
Daban, Hebatullah Hassan
Farhat, Karim
Jabry, Mansour
Canatan, Duran
al-Shebly, Mashael M.

Source

Disease Markers

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-08-27

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

Sickle cell anemia (SCA) is an inherited blood disorder with worldwide incidence of 15%; out of this, it is found in up to 20% in countries like Kingdom of Saudi Arabia and Bahrain.

The standard conventional method of detection is complete blood count (CBC) followed by hemoglobin electrophoresis or high-performance liquid chromatography (HPLC) or both.

In this context, spectral detection of variants of sickle cell anemia (SCA) is an innovative technique, which when made accurate and reliable could be an effective alternative, since the instrumentation is compact (5 kg) and hence portable.

This makes mass screening even in remote villages possible.

In this paper, we give the essential aspects of fluorescent spectral features of sickle cell trait (SCT), sickle cell disease (SCD), beta (β) thalassemia trait (BTT) + SCD, and beta (β) thalassemia disease (BTD) + SCD.

All the above four major variants could be discriminated among themselves and also from the normal control blood sample.

All these analyses could be carried out with 5 ml of blood, in a time period of 10 minutes.

The results of this paper give strong support for an alternative method, a spectral technique, for molecular-level diagnosis of sickle cell anemia and other closely related blood disorders.

American Psychological Association (APA)

Masilamani, Vadivel& Devanesan, Sandanasamy& AlQathani, Fatma& al-Shebly, Mashael M.& Daban, Hebatullah Hassan& Canatan, Duran…[et al.]. 2018. A Novel Technique of Spectral Discrimination of Variants of Sickle Cell Anemia. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153471

Modern Language Association (MLA)

Masilamani, Vadivel…[et al.]. A Novel Technique of Spectral Discrimination of Variants of Sickle Cell Anemia. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153471

American Medical Association (AMA)

Masilamani, Vadivel& Devanesan, Sandanasamy& AlQathani, Fatma& al-Shebly, Mashael M.& Daban, Hebatullah Hassan& Canatan, Duran…[et al.]. A Novel Technique of Spectral Discrimination of Variants of Sickle Cell Anemia. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153471

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1153471