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Study on the Inhibitory Effects of Ephedra Aconite Asarum Decoction on LPS-Induced Dendritic Cells
Joint Authors
Hu, Jing-Hong
Yu, Xue
Ji, Wenting
Zhang, Lanlan
Liu, Min
Wang, Qingguo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dendritic cells (DCs) can secrete cytokines stimulated by lipopolysaccharide (LPS), which leads to not just acute inflammatory responses but also Th1 polarization.
Furtherly, chronic inflammation or autoimmune diseases could be triggered.
As a classic Traditional Chinese Medicine formula, Ephedra Aconite Asarum Decoction with the main ingredients of ephedrine and hypaconitine can show effect on anti-inflammation and immunoregulation.
But it remains unclear whether Ephedra Aconite Asarum Decoction controls DCs.
In this study, we investigated the effects of Ephedra Aconite Asarum Decoction on LPS-induced bone marrow-derived DCs (BMDCs) in vitro.
We found that Ephedra Aconite Asarum Decoction lowered surface costimulators on DCs and reduced the expression of Th1 type cytokines.
Yet it is slightly beneficial for shifting to Th2.
Our work reveals that the Ephedra Aconite Asarum Decoction can regulate Th1 inflammation through intervening DCs.
American Psychological Association (APA)
Ji, Wenting& Hu, Jing-Hong& Yu, Xue& Zhang, Lanlan& Liu, Min& Wang, Qingguo. 2017. Study on the Inhibitory Effects of Ephedra Aconite Asarum Decoction on LPS-Induced Dendritic Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153480
Modern Language Association (MLA)
Ji, Wenting…[et al.]. Study on the Inhibitory Effects of Ephedra Aconite Asarum Decoction on LPS-Induced Dendritic Cells. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153480
American Medical Association (AMA)
Ji, Wenting& Hu, Jing-Hong& Yu, Xue& Zhang, Lanlan& Liu, Min& Wang, Qingguo. Study on the Inhibitory Effects of Ephedra Aconite Asarum Decoction on LPS-Induced Dendritic Cells. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153480