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The Impacts of Chrysanthemum indicum Extract on Oxidative Stress and Inflammatory Responses in Adjuvant-Induced Arthritic Rats
Joint Authors
Abdullah Al-Dhabi, Naif
Duraipandiyan, V.
Dong, Mei
Yu, Dongsheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Chrysanthemum indicum has been used as a therapeutic agent against inflammation, hypertension, and respiratory conditions for many years.
This research’s aim has been to examine the antioxidant impacts that Chrysanthemum indicum extract (CIE) has on the oxidative stress and inflammatory responses in adjuvant-induced arthritic (AA) rats.
40 rats were categorised into 4 groups according to a completely randomized approach: Group I involved normal control rats (CTRL) that received a basal diet; Group II involved arthritic control rats (CTRL-AA) that received the same diet; Group III involved rats that received a basal diet and 30 mg/kg CIE; and Group IV involved arthritic rats with the same diet as Group III rats (CIE-AA).
After injection with complete Freund’s adjuvant, body weight, arthritis score, and the serum levels of TNF-α, IL-1β, IL-6, myeloperoxidase (MPO), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-PX) were assessed.
The results demonstrated that CIE delayed the onset time of arthritis and decreased the clinical arthritis severity score (P<0.05).
Observations of CIE-AA and CTRL-AA rats demonstrated that CIE alleviates oxidative stress and inflammatory responses in CIE-AA group.
In conclusion, CIE alleviated oxidative stress and inflammatory responses, thereby highlighting its potential use as a candidate for clinical treatments of rheumatoid arthritis.
American Psychological Association (APA)
Dong, Mei& Yu, Dongsheng& Abdullah Al-Dhabi, Naif& Duraipandiyan, V.. 2017. The Impacts of Chrysanthemum indicum Extract on Oxidative Stress and Inflammatory Responses in Adjuvant-Induced Arthritic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153486
Modern Language Association (MLA)
Dong, Mei…[et al.]. The Impacts of Chrysanthemum indicum Extract on Oxidative Stress and Inflammatory Responses in Adjuvant-Induced Arthritic Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1153486
American Medical Association (AMA)
Dong, Mei& Yu, Dongsheng& Abdullah Al-Dhabi, Naif& Duraipandiyan, V.. The Impacts of Chrysanthemum indicum Extract on Oxidative Stress and Inflammatory Responses in Adjuvant-Induced Arthritic Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153486