Add-On Therapy with Traditional Chinese Medicine Improves Outcomes and Reduces Adverse Events in Hepatocellular Carcinoma: A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Yang, Zongguo
Lu, Yunfei
Chen, Xiaorong
Tang, Bozong
Liao, Xian
Xu, Qingnian
Yu, Yongchun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background and Aims.
Traditional Chinese medicine (TCM) therapy for hepatocellular carcinoma remains controversial.
This study aimed to evaluate the efficacy and safety of TCM regimens in HCC treatment.
Methods.
Randomized controlled trials (RCTs) up to June 1, 2016, of the TCM treatment for hepatocellular carcinoma were systematically identified in PubMed, CNKI, Ovid, Embase, Web of Science, Wanfang, VIP, CBM, AMED, and Cochrane Library databases.
Results.
A total of 1010 and 931 patients in 20 RCTs were randomly treated with add-on TCM therapy and conventional therapy, respectively.
The additional use of TCM significantly improved six-month, one-year, two-year, and three-year overall survival rates in HCC cases (RR = 1.3, P=0.01; RR = 1.38, P=0.0008; RR = 1.44, P<0.0001; RR = 1.31, P=0.02, resp.).
Add-on TCM therapy significantly increased PR rate and total response rate (tRR) and reduced PD rate compared to those in control group (34.4% versus 26.3%, RR = 1.30, P=0.002; 41.6% versus 31.0%, RR = 1.30, P<0.0001; and 16.6% versus 26.5%, RR = 0.64, P<0.0001, resp.).
Additionally, TCM combination therapy significantly increased the quality of life (QOL) improvement rate and reduced adverse events including leukopenia, thrombocytopenia, anemia or erythropenia, liver injury, and gastrointestinal discomfort in HCC patients (all P<0.05).
Conclusion.
Add-on therapy with TCM could improve overall survival, increase clinical tumor responses, lead to better QOL, and reduce adverse events in hepatocellular carcinoma.
American Psychological Association (APA)
Yang, Zongguo& Liao, Xian& Lu, Yunfei& Xu, Qingnian& Tang, Bozong& Chen, Xiaorong…[et al.]. 2017. Add-On Therapy with Traditional Chinese Medicine Improves Outcomes and Reduces Adverse Events in Hepatocellular Carcinoma: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153493
Modern Language Association (MLA)
Yang, Zongguo…[et al.]. Add-On Therapy with Traditional Chinese Medicine Improves Outcomes and Reduces Adverse Events in Hepatocellular Carcinoma: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1153493
American Medical Association (AMA)
Yang, Zongguo& Liao, Xian& Lu, Yunfei& Xu, Qingnian& Tang, Bozong& Chen, Xiaorong…[et al.]. Add-On Therapy with Traditional Chinese Medicine Improves Outcomes and Reduces Adverse Events in Hepatocellular Carcinoma: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153493