Systematic Review and Meta-Analysis of Diagnostic Accuracy of miRNAs in Patients with Pancreatic Cancer
Joint Authors
Sun, Xiao
Zhou, Xiaobin
Liu, Haihua
Zhang, Yuan
Zhu, Xiaoyan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
It is reported that miRNAs are aberrantly expressed in patients with pancreatic cancer.
However, the diagnostic value of miRNAs in pancreatic cancer remains controversial.
The meta-analysis was to access diagnostic accuracy of miRNAs in pancreatic cancer.
Methods.
PubMed, Scopus, Web of Science, Chinese National Knowledge Infrastructure (CNKI), WANFANG Data, China Biomedical Literature Database (CBM), and VIP databases were retrieved up to June 30, 2016, to collect articles concerning the diagnosis of miRNAs in pancreatic cancer.
The methodological quality of each study was assessed by the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2).
This meta-analysis was conducted using RevMan5.0, MetaDiSc 1.4, and Stata 12.0 software.
Results.
There are 40 articles including 109 studies.
The pooled SEN was 0.81 (95% CI, 0.80–0.82), the pooled SPE was 0.78 (95% CI, 0.77–0.79), the pooled +LR was 3.32 (95% CI, 2.92–3.80), the pooled −LR was 0.27 (95% CI, 0.24–0.31), the pooled DOR was 14.56 (95% CI, 11.55–18.34), and pooled AUC was 0.86 (95% CI, 0.84–0.88).
Discussion.
This meta-analysis demonstrated that miRNA makes a significant impact in the pancreatic cancer diagnosis with a high SEN and SPE, particularly using multiple miRNAs.
American Psychological Association (APA)
Sun, Xiao& Zhou, Xiaobin& Zhang, Yuan& Zhu, Xiaoyan& Liu, Haihua. 2018. Systematic Review and Meta-Analysis of Diagnostic Accuracy of miRNAs in Patients with Pancreatic Cancer. Disease Markers،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1153504
Modern Language Association (MLA)
Sun, Xiao…[et al.]. Systematic Review and Meta-Analysis of Diagnostic Accuracy of miRNAs in Patients with Pancreatic Cancer. Disease Markers No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1153504
American Medical Association (AMA)
Sun, Xiao& Zhou, Xiaobin& Zhang, Yuan& Zhu, Xiaoyan& Liu, Haihua. Systematic Review and Meta-Analysis of Diagnostic Accuracy of miRNAs in Patients with Pancreatic Cancer. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1153504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153504