The Protective Effect of Salidroside on Hypoxia-Induced Corpus Cavernosum Smooth Muscle Cell Phenotypic Transformation
Joint Authors
Zhao, Fan
Zhao, Jian-feng
Fu, Hui-ying
Zhang, Xiang
Yan, Jun-feng
Yang, Fan
Huang, Xiao-jun
Chen, Gang
Lv, Bo-dong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Salidroside, a major active ingredient isolated from Rhodiola rosea, has a long application in Chinese medical history.
It has widely demonstrated effects on fatigue, psychological stress, and depression and exhibits potential antihypoxia activity.
Emerging evidence shows that hypoxia is an important independent risk factor for erectile dysfunction (ED).
The aim of this study was to clarify the effect of salidroside on hypoxia-induced phenotypic transformation of corpus cavernosum smooth muscle cells (CCSMCs).
Our results showed that salidroside decreased the hypoxia-induced expression of collagen and content of vimentin, a corpus cavernosum smooth muscle synthetic protein, in vitro.
Simultaneously, salidroside increased expression of the CCSMC contractile proteins, α-smooth muscle actin (α-SMA) and desmin.
In vivo, similarly, the expressions of collagen and hypoxia-inducible factor-1α were increased in bilateral cavernous neurectomy (BCN) rats while they were decreased in the salidroside group.
Among the phenotypic proteins, α-SMA and desmin increased and vimentin decreased after treating BCN rats with salidroside compared with the BCN alone group.
Overall, our results demonstrate that salidroside has the ability to oppose hypoxia and can inhibit the CCSMC phenotypic transformation induced by hypoxia.
Salidroside may provide a new treatment method for ED.
American Psychological Association (APA)
Zhang, Xiang& Zhao, Jian-feng& Zhao, Fan& Yan, Jun-feng& Yang, Fan& Huang, Xiao-jun…[et al.]. 2017. The Protective Effect of Salidroside on Hypoxia-Induced Corpus Cavernosum Smooth Muscle Cell Phenotypic Transformation. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153528
Modern Language Association (MLA)
Zhang, Xiang…[et al.]. The Protective Effect of Salidroside on Hypoxia-Induced Corpus Cavernosum Smooth Muscle Cell Phenotypic Transformation. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1153528
American Medical Association (AMA)
Zhang, Xiang& Zhao, Jian-feng& Zhao, Fan& Yan, Jun-feng& Yang, Fan& Huang, Xiao-jun…[et al.]. The Protective Effect of Salidroside on Hypoxia-Induced Corpus Cavernosum Smooth Muscle Cell Phenotypic Transformation. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153528