Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway
Joint Authors
Lin, Jung-Yaw
Wu, Chung-Hsin
Huang, Ding-Siang
Yu, Yu-Chen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
One of the pathogenic systems of Alzheimer’s disease (AD) is the formation of β-amyloid plaques in the brains of patients, and amyloidogenic activity becomes one of the therapeutic targets.
Here, we report wogonin, one of the major active constituting components in Scutellaria baicalensis, which has the neuroprotective effects on amyloid-β peptides- (Aβ-) induced toxicity.
Oral wogonin treatment improved the performance of triple transgenic AD mice (h-APPswe, h-Tau P301L, and h-PS1 M146V) on the Morris water maze, Y-maze, and novel object recognition.
Furthermore, wogonin activated the neurite outgrowth of AD cells by increasing neurite length and complexity of Tet-On Aβ42-GFP SH-SY5Y neuroblastoma cells (AD cells) and attenuated amyloidogenic pathway by decreasing the levels of β-secretase, APP β-C-terminal fragment, Aβ-aggregation, and phosphorylated Tau.
Wogonin also increased mitochondrial membrane potential (∆ψm) and protected against apoptosis by reducing the expression of Bax and cleaved PARP.
Collectively, these results conclude that wogonin may be a promising multifunctional drug candidate for AD.
American Psychological Association (APA)
Huang, Ding-Siang& Yu, Yu-Chen& Wu, Chung-Hsin& Lin, Jung-Yaw. 2017. Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153532
Modern Language Association (MLA)
Huang, Ding-Siang…[et al.]. Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1153532
American Medical Association (AMA)
Huang, Ding-Siang& Yu, Yu-Chen& Wu, Chung-Hsin& Lin, Jung-Yaw. Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153532