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Copeptin as a Prognostic Marker in Acute Chest Pain and Suspected Acute Coronary Syndrome
Joint Authors
Nowalany-Kozielska, Ewa
Muller, Olivier
Morawiec, Beata
Kawecki, Damian
Przywara-Chowaniec, Brygida
Opara, Mariusz
Muzyk, Piotr
Ho, Lam
Tat, Lui Chun
Gabrysiak, Artur
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
In patients admitted with chest pain and suspected acute coronary syndrome (ACS), it is crucial to early identify those who are at higher risk of adverse events.
The study aim was to assess the predictive value of copeptin in patients admitted to the emergency department with chest pain and nonconclusive ECG.
Methods.
Consecutive patients suspected for an ACS were enrolled prospectively.
Copeptin and high-sensitive troponin T (hs-TnT) were measured at admission.
Patients were followed up at six and 12 months for the occurrence of death and major adverse cardiac and cerebrovascular events (MACCE).
Results.
Among 154 patients, 11 patients died and 26 experienced MACCE.
Mortality was higher in copeptin-positive than copeptin-negative patients with no difference in the rate of MACCE.
Copeptin reached the AUC 0.86 (0.75–0.97) for prognosis of mortality at six and 0.77 (0.65–0.88) at 12 months.
It was higher than for hs-TnT and their combination at both time points.
Copeptin was a strong predictor of mortality in the Cox analysis (HR14.1 at six and HR4.3 at 12 months).
Conclusions.
Copeptin appears to be an independent predictor of long-term mortality in a selected population of patients suspected for an ACS.
The study registration number is ISRCTN14112941.
American Psychological Association (APA)
Morawiec, Beata& Kawecki, Damian& Przywara-Chowaniec, Brygida& Opara, Mariusz& Muzyk, Piotr& Ho, Lam…[et al.]. 2018. Copeptin as a Prognostic Marker in Acute Chest Pain and Suspected Acute Coronary Syndrome. Disease Markers،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153533
Modern Language Association (MLA)
Morawiec, Beata…[et al.]. Copeptin as a Prognostic Marker in Acute Chest Pain and Suspected Acute Coronary Syndrome. Disease Markers No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1153533
American Medical Association (AMA)
Morawiec, Beata& Kawecki, Damian& Przywara-Chowaniec, Brygida& Opara, Mariusz& Muzyk, Piotr& Ho, Lam…[et al.]. Copeptin as a Prognostic Marker in Acute Chest Pain and Suspected Acute Coronary Syndrome. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153533