Copeptin as a Prognostic Marker in Acute Chest Pain and Suspected Acute Coronary Syndrome

Joint Authors

Nowalany-Kozielska, Ewa
Muller, Olivier
Morawiec, Beata
Kawecki, Damian
Przywara-Chowaniec, Brygida
Opara, Mariusz
Muzyk, Piotr
Ho, Lam
Tat, Lui Chun
Gabrysiak, Artur

Source

Disease Markers

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-01-24

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

Background.

In patients admitted with chest pain and suspected acute coronary syndrome (ACS), it is crucial to early identify those who are at higher risk of adverse events.

The study aim was to assess the predictive value of copeptin in patients admitted to the emergency department with chest pain and nonconclusive ECG.

Methods.

Consecutive patients suspected for an ACS were enrolled prospectively.

Copeptin and high-sensitive troponin T (hs-TnT) were measured at admission.

Patients were followed up at six and 12 months for the occurrence of death and major adverse cardiac and cerebrovascular events (MACCE).

Results.

Among 154 patients, 11 patients died and 26 experienced MACCE.

Mortality was higher in copeptin-positive than copeptin-negative patients with no difference in the rate of MACCE.

Copeptin reached the AUC 0.86 (0.75–0.97) for prognosis of mortality at six and 0.77 (0.65–0.88) at 12 months.

It was higher than for hs-TnT and their combination at both time points.

Copeptin was a strong predictor of mortality in the Cox analysis (HR14.1 at six and HR4.3 at 12 months).

Conclusions.

Copeptin appears to be an independent predictor of long-term mortality in a selected population of patients suspected for an ACS.

The study registration number is ISRCTN14112941.

American Psychological Association (APA)

Morawiec, Beata& Kawecki, Damian& Przywara-Chowaniec, Brygida& Opara, Mariusz& Muzyk, Piotr& Ho, Lam…[et al.]. 2018. Copeptin as a Prognostic Marker in Acute Chest Pain and Suspected Acute Coronary Syndrome. Disease Markers،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153533

Modern Language Association (MLA)

Morawiec, Beata…[et al.]. Copeptin as a Prognostic Marker in Acute Chest Pain and Suspected Acute Coronary Syndrome. Disease Markers No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1153533

American Medical Association (AMA)

Morawiec, Beata& Kawecki, Damian& Przywara-Chowaniec, Brygida& Opara, Mariusz& Muzyk, Piotr& Ho, Lam…[et al.]. Copeptin as a Prognostic Marker in Acute Chest Pain and Suspected Acute Coronary Syndrome. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153533

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1153533