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Effectiveness of Antihyperglycemic Effect of Momordica charantia: Implication of T-Cell Cytokines
Joint Authors
Yessoufou, Akadiri
Nekoua, Magloire P.
Fachinan, Rufine
Moutairou, Kabirou
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background/Objective.
We investigate the effect of antidiabetic Momordica charantia fruit juice on T cells’ differentiation, through plasmatic cytokine quantification in type 1 diabetic rats (T1D).
Methods.
Male Wistar rats were rendered diabetic by the injection of five low doses of streptozotocin.
Then, animals were treated with Momordica charantia fruit juice for 28 consecutive days.
Plasmatic levels of Th1 interleukin- (IL-) 02 and interferon- (IFN-) γ, Th2 (IL-4), and regulatory (IL-10) cytokines were determined in rats.
Results.
We observed that fruit juice induced a significant decrease in blood glucose of T1D rats.
Besides, the concentrations of IL-2 and IFN-γ significantly increased while those of IL-4 and IL-10 diminished in diabetic rats compared to control animals.
Interestingly, after treatment with Momordica charantia fruit juice, IL-4 and IL-10 levels significantly increased in diabetic rats, while IL-2 and IFN-γ concentrations decreased, suggesting a Th2 phenotype in these animals.
Phytochemical analysis of the fruit juice revealed the presence of tannins, flavonoids, and coumarins, compounds which possess antioxidant activity.
Conclusion.
This study shows that Momordica charantia fruit juice, by lowering the hyperglycemia, induced a shift of proinflammatory Th1 phenotype in T1D rats towards a favorable anti-inflammatory Th2 status.
These effects might be due to the presence of antioxidant compounds in the juice and confirms the use of this plant in the treatment of autoimmune type 1 diabetes.
American Psychological Association (APA)
Fachinan, Rufine& Yessoufou, Akadiri& Nekoua, Magloire P.& Moutairou, Kabirou. 2017. Effectiveness of Antihyperglycemic Effect of Momordica charantia: Implication of T-Cell Cytokines. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153574
Modern Language Association (MLA)
Fachinan, Rufine…[et al.]. Effectiveness of Antihyperglycemic Effect of Momordica charantia: Implication of T-Cell Cytokines. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153574
American Medical Association (AMA)
Fachinan, Rufine& Yessoufou, Akadiri& Nekoua, Magloire P.& Moutairou, Kabirou. Effectiveness of Antihyperglycemic Effect of Momordica charantia: Implication of T-Cell Cytokines. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153574