![](/images/graphics-bg.png)
Therapeutic Effect and Mechanism of Oxytropis falcata Gel on Deep Second-Degree Burn in Rats
Joint Authors
Lin, Xiao-Feng
Chen, Kai-Jie
Shi, He-Kun
Yu, Le
Chen, Jin-Shan
Fei, Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Oxytropis falcata has long been used to treat inflammation, sores, and bleeding in Tibet.
However, the burn remedy and underlying molecular mechanisms are not well understood.
This study is aimed at assessing the effect of Oxytropis falcate gel (OFG) on deep second-degree burn rats and exploring its mechanism.
Wistar rats with second-degree burn were treated with OFG and silver sulfadiazine.
Immunohistochemical detections for EGF and VEGF were performed, and ELISA detections for EGF, VEGF, p38, and IL-1β in serum were determined.
Rats treated with OFG (25, 50 g/kg) consisted of the major rhamnocitrin-3-O-β-neohesperidoside significantly accelerated incrustation (P<0.001) and decrustation (P<0.001).
According to HE staining, edema and infiltration of inflammatory cells decrease apparently with good hyperplasia and incrustation in administration groups (7 d).
The expressions of EGF and CD34 in OFG (25, 50 g/kg) treatment increased obviously from immunohistochemical assessment (7 d).
Serum EGF expression reached 321.27±7.20 ng/mL by OFG treatment, while p38 (P<0.05) and IL-1β (P<0.05) levels were significantly lower than the model and vehicle groups from day 1 to day 7.
OFG possesses potential wound healing activities.
The mechanism may be related to the increasing of biosynthesis and the releasing of EGF and CD34 and the decreasing p38 and IL-1β levels.
American Psychological Association (APA)
Lin, Xiao-Feng& Chen, Kai-Jie& Shi, He-Kun& Yu, Le& Chen, Jin-Shan& Fei, Yan. 2017. Therapeutic Effect and Mechanism of Oxytropis falcata Gel on Deep Second-Degree Burn in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153576
Modern Language Association (MLA)
Lin, Xiao-Feng…[et al.]. Therapeutic Effect and Mechanism of Oxytropis falcata Gel on Deep Second-Degree Burn in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1153576
American Medical Association (AMA)
Lin, Xiao-Feng& Chen, Kai-Jie& Shi, He-Kun& Yu, Le& Chen, Jin-Shan& Fei, Yan. Therapeutic Effect and Mechanism of Oxytropis falcata Gel on Deep Second-Degree Burn in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153576