NaoxintongPPAR γ Signaling Inhibits Cardiac Hypertrophy via Activation of Autophagy
Joint Authors
Chen, Lu
Hou, Yongzhong
Yuan, Shuping
Jin, Jianhua
Wang, Hong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
As a traditional Chinese medicine, Naoxintong capsule (NXT) has been approved by China Food and Drug Administration (CFDA), which is used for cardiocerebrovascular disease treatment.
Here we found that NXT extract significantly promoted H9c2 cardiomyocyte cell autophagy involved in increased autophagy-associated gene expression leading to inhibition of mTOR signaling.
Moreover, NXT extract increased PPARγ protein expression and transcription activity of H9c2 cell.
Consistent with this, in PPARγ gene silenced H9c2 cells, NXT had no effect on autophagy and mTOR signaling.
Furthermore, NXT/PPARγ-mediated H9c2 autophagy led to inhibition of cardiomyocyte cell hypertrophy.
These findings suggest that the extract of NXT inhibited H9c2 cardiomyocyte cell hypertrophy via PPARγ-mediated cell autophagy.
American Psychological Association (APA)
Yuan, Shuping& Jin, Jianhua& Chen, Lu& Hou, Yongzhong& Wang, Hong. 2017. NaoxintongPPAR γ Signaling Inhibits Cardiac Hypertrophy via Activation of Autophagy. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153582
Modern Language Association (MLA)
Yuan, Shuping…[et al.]. NaoxintongPPAR γ Signaling Inhibits Cardiac Hypertrophy via Activation of Autophagy. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153582
American Medical Association (AMA)
Yuan, Shuping& Jin, Jianhua& Chen, Lu& Hou, Yongzhong& Wang, Hong. NaoxintongPPAR γ Signaling Inhibits Cardiac Hypertrophy via Activation of Autophagy. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153582