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A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts
Joint Authors
Brito-Mendoza, Luisana
Irigoyen-Camacho, María Esther
Martinez, Guillermo
Sánchez-Romero, Celeste
Mosqueda-Taylor, Adalberto
Bologna-Molina, Ronell
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Objective.
Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts.
The aim was to compare the expression of Ki-67, CD138, and the molecular triad RANK, RANKL, and OPG in odontogenic keratocysts (OKC), unicystic ameloblastomas (UA), and dentigerous cysts (DC).
Methods.
Immunohistochemistry for Ki-67, CD138, RANK, RANKL, and OPG was performed in 58 odontogenic cystic lesions (22 OKC, 17 DC, and 19 UA).
Results.
A higher expression of Ki-67 was identified in OKC as compared to UA (p<0.0001).
UA exhibited a greater loss of CD138 expression versus OKCs (p>0.0034).
RANKL was expressed higher in the epithelium (p=0.0002) and in the stroma (p=0.0004) of UA.
DC had a lower expression of these markers.
Conclusion.
Higher RANKL expression together with the reduction on CD138 expression in UA could be linked to a greater invasive and destructive potential, while the increased proliferation rate observed in OKC could be related to its continuous intrabony growth.
The expansion of DC does not seem to be related to such factors, justifying the different therapeutic approaches proposed for each of these entities.
American Psychological Association (APA)
Brito-Mendoza, Luisana& Bologna-Molina, Ronell& Irigoyen-Camacho, María Esther& Martinez, Guillermo& Sánchez-Romero, Celeste& Mosqueda-Taylor, Adalberto. 2018. A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153586
Modern Language Association (MLA)
Brito-Mendoza, Luisana…[et al.]. A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153586
American Medical Association (AMA)
Brito-Mendoza, Luisana& Bologna-Molina, Ronell& Irigoyen-Camacho, María Esther& Martinez, Guillermo& Sánchez-Romero, Celeste& Mosqueda-Taylor, Adalberto. A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153586