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Effect of QSKL on MAPK and RhoA Pathways in a Rat Model of Heart Failure
Joint Authors
Wang, Wei
Guo, Shuzhen
Wang, Qiyan
Xia, Kai
Zeng, Zifan
Wang, Yong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Qishenkeli (QSKL) is one of the Chinese medicine formulae for treating heart failure and has been shown to have an antifibrotic effect.
However, the mechanism of its therapeutic effects remains unclear.
In this study, we aimed to explore whether QSKL could exert an antifibrotic effect by attenuating ras homolog family member A (RhoA) and mitogen activated protein kinase (MAPK) pathways.
Rats were randomly divided into sham group, model group, QSKL group, and positive control group.
Heart failure was induced by ligation of the left ventricle anterior descending artery.
Cardiac functions were measured by echocardiography and collagen deposition was assessed by Masson staining.
Expressions of the key molecules involved in the RhoA and MAPK pathways were also measured.
Twenty-one days after surgery, cardiac functions were severely impaired and collagen deposition was remarkable, while QSKL treatment could improve heart functions and alleviate collagen deposition.
Further results demonstrated that the effects may be mediated by suppressing expressions of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK).
Moreover, expressions of RhoA, Rho-associated protein kinase 1/2 (ROCK1/2), and phosphorylated myosin light chain (p-MLC) were also downregulated by QSKL compared with the model group.
The cardioprotective mechanism of QSKL on heart failure is probably mediated by regulating both the MAPK and RhoA signaling pathways.
American Psychological Association (APA)
Xia, Kai& Wang, Qiyan& Guo, Shuzhen& Zeng, Zifan& Wang, Yong& Wang, Wei. 2017. Effect of QSKL on MAPK and RhoA Pathways in a Rat Model of Heart Failure. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153595
Modern Language Association (MLA)
Xia, Kai…[et al.]. Effect of QSKL on MAPK and RhoA Pathways in a Rat Model of Heart Failure. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1153595
American Medical Association (AMA)
Xia, Kai& Wang, Qiyan& Guo, Shuzhen& Zeng, Zifan& Wang, Yong& Wang, Wei. Effect of QSKL on MAPK and RhoA Pathways in a Rat Model of Heart Failure. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153595