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Efficacy of Topical Compound Danxiong Granules for Treatment of Dermatologic Toxicities Induced by Targeted Anticancer Therapy: A Randomized, Double-Blind, Placebo-Controlled Trial
Joint Authors
Chen, Wei
Tian, Aiping
Zhou, Aiping
Bi, Xinyu
Hu, Shangying
Jiang, Zhichao
Zhang, Wen
Huang, Zhen
Shi, Hongzhe
Yang, Boyan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Dermatologic toxicities resulting in dose reduction or discontinuation of treatment pose challenges for targeted anticancer therapies.
We conducted this randomized, double-blind, placebo-controlled trial to investigate the efficacy of topical application of Compound Danxiong Granules (CDG) for treatment of dermatologic toxicities associated with targeted anticancer therapies.
One hundred and ten patients with dermatologic toxicities induced by targeted anticancer therapies were randomly assigned to CDG or placebo group.
Each crude herb (Rhizoma Chuanxiong, Paeonia suffruticosa Andr., Cortex Phellodendri, Geranium sibiricum L., and Flos Carthami) was prepared as an instant herbal powder.
Application of the CDG via topical washes lasted 20 minutes, twice daily, for 10 days.
The primary outcome was the total effective rate, defined as reduction in at least one grade of skin toxicity.
The total effective rate was 77.61% (52/67) in the CDG group and 27.27% (9/33) in the placebo group (P<0.0001).
Compared to the placebo treatment, CDG treatment achieved a higher total effective rate for hand-foot skin reaction (95.45% versus 27.27%), acneiform eruption (69.23% versus 30.78%), and paronychia (68.42% versus 22.22%).
Topical application of CDG can effectively attenuate dermatologic toxicities induced by targeted anticancer therapies.
The effect of CDG was more pronounced in hand-foot skin reaction.
American Psychological Association (APA)
Tian, Aiping& Zhou, Aiping& Bi, Xinyu& Hu, Shangying& Jiang, Zhichao& Zhang, Wen…[et al.]. 2017. Efficacy of Topical Compound Danxiong Granules for Treatment of Dermatologic Toxicities Induced by Targeted Anticancer Therapy: A Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153604
Modern Language Association (MLA)
Tian, Aiping…[et al.]. Efficacy of Topical Compound Danxiong Granules for Treatment of Dermatologic Toxicities Induced by Targeted Anticancer Therapy: A Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1153604
American Medical Association (AMA)
Tian, Aiping& Zhou, Aiping& Bi, Xinyu& Hu, Shangying& Jiang, Zhichao& Zhang, Wen…[et al.]. Efficacy of Topical Compound Danxiong Granules for Treatment of Dermatologic Toxicities Induced by Targeted Anticancer Therapy: A Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153604