![](/images/graphics-bg.png)
Endoplasmic Reticulum Stress Markers and Their Possible Implications in Leprosy’s Pathogenesis
Joint Authors
Quaresma, Juarez Antônio Simões
Sotto, Mirian Nacagami
Hirai, Kelly Emi
de Sousa, Jorge Rodrigues
Silva, Luciana Mota
Junior, Leônidas Braga Dias
Furlaneto, Ismari Perini
Carneiro, Francisca Regina Oliveira
de Souza Aarão, Tinara Leila
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mycobacterium leprae causes leprosy, a dermatoneurological disease which affects the skin and peripheral nerves.
One of several cellular structures affected during M.
leprae infection is the endoplasmic reticulum (ER).
Infection by microorganisms can result in ER stress and lead to the accumulation of unfolded or poorly folded proteins.
To restore homeostasis in the cell, the cell induces a series of signaling cascades known as the unfolded protein response called UPR (unfolded protein response).
The present work is aimed at investigating the in situ expression of these markers in cutaneous lesions of clinical forms of leprosy and establish possible correlation expression patterns and types of lesion.
A total of 43 samples from leprosy patients were analyzed by immunohistochemistry with monoclonal antibodies against GRP78/BiP, PERK, IRE1α, and ATF6.
A statistically significant difference between the indeterminate, tuberculoid, and lepromatous clinical forms was detected, with high expression of GRP78/BiP, PERK, IRE1α, and ATF6 in tuberculoid forms (TT) when compared to lepromatous leprosy (LL) and indeterminate (I) leprosy.
These results represent the first evidence of ER stress in samples of skin lesions from leprosy patients.
We believe that they will provide better understanding of the complex pathogenesis of the disease and facilitate further characterization of the cascade of molecular events elicited during infection.
American Psychological Association (APA)
Hirai, Kelly Emi& de Sousa, Jorge Rodrigues& Silva, Luciana Mota& Junior, Leônidas Braga Dias& Furlaneto, Ismari Perini& Carneiro, Francisca Regina Oliveira…[et al.]. 2018. Endoplasmic Reticulum Stress Markers and Their Possible Implications in Leprosy’s Pathogenesis. Disease Markers،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1153606
Modern Language Association (MLA)
Hirai, Kelly Emi…[et al.]. Endoplasmic Reticulum Stress Markers and Their Possible Implications in Leprosy’s Pathogenesis. Disease Markers No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1153606
American Medical Association (AMA)
Hirai, Kelly Emi& de Sousa, Jorge Rodrigues& Silva, Luciana Mota& Junior, Leônidas Braga Dias& Furlaneto, Ismari Perini& Carneiro, Francisca Regina Oliveira…[et al.]. Endoplasmic Reticulum Stress Markers and Their Possible Implications in Leprosy’s Pathogenesis. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1153606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153606