Acupuncture Stimulation at GB34 Restores MPTP-Induced Neurogenesis Impairment in the Subventricular Zone of Mice
Joint Authors
Kim, Seung-Tae
Kim, Dong-Soo
Ha, Ki-Tae
Jeon, Hyongjun
Ryu, Sun
Koo, Sungtae
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Adult neurogenesis has recently been considered a new therapeutic paradigm of Parkinson’s disease.
In this study, we investigated whether acupuncture restores 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced impaired neurogenesis in the subventricular zone (SVZ).
Male C57BL/6 mice were given 30 mg/kg of MPTP intraperitoneally once a day for 5 days, after which they were intraperitoneally injected with 50 mg/kg of bromodeoxyuridine (BrdU) and given acupuncture stimulation at HT7 or GB34 for 12 consecutive days.
Dopaminergic neuronal survival in the nigrostriatal pathway and cell proliferation in the SVZ was then evaluated by immunostaining.
MPTP administration induced dopaminergic neuronal death in the nigrostriatal pathway, which was suppressed by acupuncture stimulation at GB34.
MPTP administration also suppressed the number of BrdU-positive cells and glial fibrillary acidic protein/BrdU-positive cells and increased the number of doublecortin/BrdU-positive cells in the SVZ, which were restored by acupuncture stimulation at GB34.
These results indicate that acupuncture stimulation at GB34 restores MPTP-induced neurogenesis impairment.
American Psychological Association (APA)
Jeon, Hyongjun& Ryu, Sun& Kim, Dong-Soo& Koo, Sungtae& Ha, Ki-Tae& Kim, Seung-Tae. 2017. Acupuncture Stimulation at GB34 Restores MPTP-Induced Neurogenesis Impairment in the Subventricular Zone of Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153607
Modern Language Association (MLA)
Jeon, Hyongjun…[et al.]. Acupuncture Stimulation at GB34 Restores MPTP-Induced Neurogenesis Impairment in the Subventricular Zone of Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153607
American Medical Association (AMA)
Jeon, Hyongjun& Ryu, Sun& Kim, Dong-Soo& Koo, Sungtae& Ha, Ki-Tae& Kim, Seung-Tae. Acupuncture Stimulation at GB34 Restores MPTP-Induced Neurogenesis Impairment in the Subventricular Zone of Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153607