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Visfatin Serum Levels Predict Mortality in Critically Ill Patients
Joint Authors
Koch, Alexander
Weiskirchen, Ralf
Yagmur, Eray
Bruensing, Jan
Herbers, Ulf
Krusch, Alexander
Koek, Ger H.
Trautwein, Christian
Tacke, Frank
Buendgens, Lukas
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The adipokine visfatin, also termed pre-B-cell colony-enhancing factor (PBEF), is mainly derived from adipose tissue but has been implicated in the regulation of innate immune responses.
We hypothesized that visfatin could be a potential circulating biomarker in critical illness and sepsis.
We therefore measured serum levels of visfatin in a cohort of 229 critically ill medical patients upon admission to the intensive care unit (ICU).
In comparison to 53 healthy controls, visfatin levels were significantly elevated in medical ICU patients, especially in patients with sepsis.
Visfatin serum concentrations were strongly associated with disease severity and organ failure but did not differ between patients with or without obesity or type 2 diabetes.
Visfatin levels correlated with biomarkers of renal failure, liver dysfunction, and other adipokines (e.g., resistin, leptin, and adiponectin) in critically ill patients.
High visfatin levels at ICU admission indicated an increased mortality, both at the ICU and during long-term follow-up of approximately two years.
Our data therefore demonstrate that circulating visfatin is a valuable biomarker for risk and prognosis assessment in critically ill patients.
Furthermore, visfatin seems to be involved in the pathogenesis of excessive systemic inflammation, supporting further research on visfatin as a therapeutic target.
American Psychological Association (APA)
Koch, Alexander& Weiskirchen, Ralf& Krusch, Alexander& Bruensing, Jan& Buendgens, Lukas& Herbers, Ulf…[et al.]. 2018. Visfatin Serum Levels Predict Mortality in Critically Ill Patients. Disease Markers،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153628
Modern Language Association (MLA)
Koch, Alexander…[et al.]. Visfatin Serum Levels Predict Mortality in Critically Ill Patients. Disease Markers No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1153628
American Medical Association (AMA)
Koch, Alexander& Weiskirchen, Ralf& Krusch, Alexander& Bruensing, Jan& Buendgens, Lukas& Herbers, Ulf…[et al.]. Visfatin Serum Levels Predict Mortality in Critically Ill Patients. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153628